MICA/B Antibody (A-9): sc-376590
- MICA/B Antibody (A-9) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 99-137 within an internal region of MICA of human origin
- recommended for detection of MICA and MICB of and human origin by WB, IP, IF and ELISA
- See MICA/B (F-6): sc-137242 for MICA/B antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MICA/B Antibody (A-9) for WB applications. These reagents are now offered in bundles with MICA/B Antibody (A-9) (see ordering information below).
QUICK LINKS
MICA/B Antibody (A-9) is a mouse monoclonal IgG1 antibody that detects MICA in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MICA antibody (A-9) targets MICA, a stress-induced antigen closely related to major histocompatibility complex (MHC) class I molecules, which plays a crucial role in the immune response by signaling cellular distress. MICA is predominantly expressed on the surface of epithelial cells, particularly during conditions of stress such as heat shock or proliferation, making MICA an important marker for identifying tumor cells in epithelial tissues. MICA expression on these cells is significant as MICA can activate Vδ1 γδ T cells, which are part of the innate immune system, thereby facilitating a rapid immune response to potential threats. This interaction underscores MICA′s importance in immune surveillance and highlights MICA′s potential as a therapeutic target in cancer immunotherapy. MICA/B (A-9) antibody is an essential tool for researchers studying the dynamics of immune responses in various pathological conditions, particularly in the context of epithelial tumors.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MICA/B Antibody (A-9) References:
- Association of MICA and MICB alleles with symptomatic dengue infection. | García, G., et al. 2011. Hum Immunol. 72: 904-7. PMID: 21762746
- MICA/B expression in macrophage foam cells infiltrating atherosclerotic plaques. | Ikeshita, S., et al. 2014. Exp Mol Pathol. 97: 171-5. PMID: 24997223
- New biomarkers for antenatal infection: MICA and MICB gene expression in preterm babies. | Özlü, F., et al. 2019. J Matern Fetal Neonatal Med. 32: 579-583. PMID: 28969449
- BCL11B regulates MICA/B-mediated immune response by acting as a competitive endogenous RNA. | Qian, M., et al. 2020. Oncogene. 39: 1514-1526. PMID: 31673069
- Inhibition of MICA and MICB Shedding Elicits NK-Cell-Mediated Immunity against Tumors Resistant to Cytotoxic T Cells. | Ferrari de Andrade, L., et al. 2020. Cancer Immunol Res. 8: 769-780. PMID: 32209637
- Establishment of HLA class I and MICA/B null HEK-293T panel expressing single MICA alleles to detect anti-MICA antibodies. | Jeon, JH., et al. 2021. Sci Rep. 11: 15716. PMID: 34344955
- NLRP3 Deficiency in Hepatocellular Carcinoma Enhances Surveillance of NK-92 through a Modulation of MICA/B. | Lee, HH., et al. 2021. Int J Mol Sci. 22: PMID: 34502191
- Promoting T and NK cell attack: preserving tumor MICA/B by vaccines. | Cichocki, F. and Miller, JS. 2022. Cell Res. 32: 961-962. PMID: 35821089
- MUC1-C is a master regulator of MICA/B NKG2D ligand and exosome secretion in human cancer cells. | Morimoto, Y., et al. 2023. J Immunother Cancer. 11: PMID: 36754452
- Exploration of the role of NKG2D ligands MICA and MICB in JAK2 V617F-positive myeloproliferative neoplasms. | Ivanova, M., et al. 2023. HLA. 102: 168-178. PMID: 37002719
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MICA/B Antibody (A-9) | sc-376590 | 200 µg/ml | $322.00 | |||
MICA/B Antibody (A-9): m-IgG Fc BP-HRP Bundle | sc-540604 | 200 µg Ab; 10 µg BP | $361.00 | |||
MICA/B Antibody (A-9): m-IgG1 BP-HRP Bundle | sc-542238 | 200 µg Ab; 20 µg BP | $361.00 | |||
MICA/B (A-9) Neutralizing Peptide | sc-376590 P | 100 µg/0.5 ml | $69.00 |