MHC class II Antibody (ER-TR2): sc-59317

MHC class II Antibody (ER-TR2) is a rat monoclonal IgG2b antibody that detects MHC class II in mouse samples through applications such as immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). MHC class II molecules play a crucial role in the immune response by presenting processed exogenous antigens to helper T lymphocytes, which are essential for orchestrating adaptive immunity. These molecules are primarily located on the surface of professional antigen-presenting cells, such as dendritic cells, macrophages, and B cells, where they facilitate the activation of CD4+ T cells. The ability of MHC class II to bind longer peptide fragments, typically ranging from 13 to 18 amino acids, is vital for the effective presentation of a diverse array of antigens, thereby enhancing the immune system′s ability to recognize and respond to pathogens. The interaction between MHC class II and T cell receptors is a key event in the initiation of immune responses, making anti-MHC class II antibody (ER-TR2) critical for understanding various immunological processes and potential therapeutic interventions. MHC class II (ER-TR2) antibody is an invaluable tool for researchers investigating the complexities of immune regulation and T cell activation in mouse models.

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MHC class II Antibody (ER-TR2) References:

1. Endothelial expression of MHC class II molecules in autoimmune disease.  |  Turesson, C. 2004. Curr Pharm Des. 10: 129-43. PMID: 14754393
2. MHC-class-II-deficiency impairs wound healing.  |  Schäffer, M., et al. 2007. J Surg Res. 138: 100-5. PMID: 17161429
3. MHC class II molecules on the move for successful antigen presentation.  |  Rocha, N. and Neefjes, J. 2008. EMBO J. 27: 1-5. PMID: 18046453
4. MHC Class II Polymorphisms, Autoreactive T-Cells, and Autoimmunity.  |  Tsai, S. and Santamaria, P. 2013. Front Immunol. 4: 321. PMID: 24133494
5. MHC class II presentation is controlled by the lysosomal small GTPase, Arl8b.  |  Michelet, X., et al. 2015. J Immunol. 194: 2079-88. PMID: 25637027
6. Blocking MHC class II on human endothelium mitigates acute rejection.  |  Abrahimi, P., et al. 2016. JCI Insight. 1: PMID: 26900601
7. Ubiquitination of MHC Class II by March-I Regulates Dendritic Cell Fitness.  |  Kim, HJ., et al. 2021. J Immunol. 206: 494-504. PMID: 33318291
8. Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules.  |  Jin, H., et al. 2022. Sci Adv. 8: eabj9867. PMID: 35245125
9. Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity.  |  Eshleman, EM., et al. 2023. J Clin Invest. 133: PMID: 36602872
10. MHC class II genes mediate susceptibility and resistance to coronavirus infections in bats.  |  Schmid, DW., et al. 2023. Mol Ecol. 32: 3989-4002. PMID: 37203872

The preferred MHC class II antibody is MHC class II Antibody (IBL-5/22): sc-59322.