MHC class Iα Antibody (6F149): sc-71256

MHC class Iα Antibody (6F149) is a mouse monoclonal IgG1 antibody that detects MHC class I alpha protein of avian origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-MHC class I alpha antibody (6F149) is available as the non-conjugated format. The major histocompatibility complex (MHC) class I molecules are crucial for the immune response, as they present endogenous peptides to CD8+ T lymphocytes, thereby playing a vital role in the recognition of infected or malignant cells. MHC class I alpha protein is primarily located on the surface of nearly all nucleated cells, which is essential for the immune system′s ability to monitor cellular health and detect abnormalities. By presenting peptide fragments derived from proteins synthesized within the cell, MHC class I molecules enable T cells to identify and eliminate cells that are infected with viruses or have undergone malignant transformation. The structural integrity of MHC class I alpha protein, which includes a heavy chain that dimerizes with β-2-Microglobulin, is critical for its function, as any alterations can lead to impaired immune responses and increased susceptibility to infections or cancer. MHC class I alpha (6F149) monoclonal antibody is an invaluable tool for researchers studying immune responses in avian species, providing insights into the complex interactions between MHC molecules and T lymphocytes.

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MHC class Iα Antibody (6F149) References:

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The preferred MHC class I antibody is MHC class I Antibody (W6/32): sc-32235.