MGMT Antibody (E-1): sc-166528
- MGMT Antibody (E-1) is a mouse monoclonal IgG2a κ MGMT antibody, cited in 9 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 9-24 at the N-terminus of MGMT of human origin
- MGMT Antibody (E-1) is recommended for detection of MGMT of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-MGMT Antibody (E-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MGMT Antibody (E-1) for WB and IHC(P) applications. These reagents are now offered in bundles with MGMT Antibody (E-1) (see ordering information below).
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SEE ALSO...
MGMT Antibody (E-1) is a mouse monoclonal IgG2a kappa light chain antibody specific for an epitope mapping between amino acids 9-24 at the N-terminus of human MGMT, showing reactivity with MGMT from mouse, rat, and human origins by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MGMT, also known as O6-methylguanine-DNA methyltransferase or O-6-alkylguanine DNA alkyltransferase (AGT), is a vital DNA repair enzyme that removes mutagenic and cytotoxic alkyl groups from the O6 position of guanine in DNA. Such alkylation lesions can lead to mispairing during DNA replication, resulting in mutations and potentially carcinogenesis. MGMT is predominantly located in the cell nucleus, where direct access to genomic DNA allows for efficient repair of DNA damage before cell division occurs. Nuclear localization ensures maintenance of genomic stability and prevents propagation of DNA errors to daughter cells. High levels of MGMT can confer resistance to alkylating chemotherapeutic agents, making MGMT expression significant in cancer research and therapy development. Anti-MGMT antibody (E-1) serves as a valuable tool for researchers investigating DNA repair mechanisms and MGMT expression in cancer treatment outcomes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MGMT Antibody (E-1) | sc-166528 | 200 µg/ml | $316.00 | |||
MGMT Antibody (E-1): m-IgG Fc BP-HRP Bundle | sc-528986 | 200 µg Ab; 10 µg BP | $354.00 | |||
MGMT Antibody (E-1): m-IgGκ BP-HRP Bundle | sc-521642 | 200 µg Ab, 40 µg BP | $354.00 | |||
MGMT Antibody (E-1): m-IgG2a BP-HRP Bundle | sc-547227 | 200 µg Ab; 10 µg BP | $354.00 | |||
MGMT Antibody (E-1) AC | sc-166528 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MGMT Antibody (E-1) HRP | sc-166528 HRP | 200 µg/ml | $316.00 | |||
MGMT Antibody (E-1) FITC | sc-166528 FITC | 200 µg/ml | $330.00 | |||
MGMT Antibody (E-1) PE | sc-166528 PE | 200 µg/ml | $343.00 | |||
MGMT Antibody (E-1) Alexa Fluor® 488 | sc-166528 AF488 | 200 µg/ml | $357.00 | |||
MGMT Antibody (E-1) Alexa Fluor® 546 | sc-166528 AF546 | 200 µg/ml | $357.00 | |||
MGMT Antibody (E-1) Alexa Fluor® 594 | sc-166528 AF594 | 200 µg/ml | $357.00 | |||
MGMT Antibody (E-1) Alexa Fluor® 647 | sc-166528 AF647 | 200 µg/ml | $357.00 | |||
MGMT Antibody (E-1) Alexa Fluor® 680 | sc-166528 AF680 | 200 µg/ml | $357.00 | |||
MGMT Antibody (E-1) Alexa Fluor® 790 | sc-166528 AF790 | 200 µg/ml | $357.00 | |||
MGMT (E-1) Neutralizing Peptide | sc-166528 P | 100 µg/0.5 ml | $68.00 |