mGluR-4 Antibody (B-8): sc-376485
- mGluR-4 Antibody (B-8) is a mouse monoclonal IgG2a κ mGluR-4 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 364-403 mapping within an internal region of mGluR-4 of human origin
- mGluR-4 Antibody (B-8) is recommended for detection of mGluR-4 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and bovine and porcine
- Anti-mGluR-4 Antibody (B-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for mGluR-4 Antibody (B-8) for WB applications. These reagents are now offered in bundles with mGluR-4 Antibody (B-8) (see ordering information below).
mGluR-4 Antibody (B-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects mGluR-4 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-mGluR-4 antibody (B-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. mGluR-4, a member of the metabotropic glutamate receptor family, plays a crucial role in modulating synaptic transmission and plasticity in the central nervous system, particularly in the cerebellum where mGluR-4 is highly expressed. mGluR-4 is involved in the regulation of neurotransmitter release and has been implicated in various neurological disorders, making mGluR-4 an important target for research into therapeutic interventions. Notably, mGluR-4 interacts with specific proteins such as PRKCABP, which can influence signaling pathways and functional outcomes. Understanding these interactions is vital for elucidating the complex mechanisms of glutamate signaling and its implications in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
mGluR-4 Antibody (B-8) References:
- Mutation screening of the metabotropic glutamate receptor mGluR4 (GRM4) gene in patients with schizophrenia. | Ohtsuki, T., et al. 2001. Psychiatr Genet. 11: 79-83. PMID: 11525421
- Metabotropic glutamate receptor 4 expression in colorectal carcinoma and its prognostic significance. | Chang, HJ., et al. 2005. Clin Cancer Res. 11: 3288-95. PMID: 15867225
- Altered glutamate and GABA release within thalamocortical circuitry in metabotropic glutamate receptor 4 knockout mice. | Wang, X., et al. 2005. Neuroscience. 134: 1195-203. PMID: 16039800
- Targeting the metabotropic glutamate receptor mGluR4 for the treatment of diseases of the central nervous system. | Marino, MJ., et al. 2005. Curr Top Med Chem. 5: 885-95. PMID: 16178733
- Immunocytochemical localization of metabotropic (mGluR2/3 and mGluR4a) and ionotropic (GluR2/3) glutamate receptors in adrenal medullary ganglion cells. | Sarría, R., et al. 2006. Histol Histopathol. 21: 141-7. PMID: 16329038
- The metabotropic glutamate receptor 4 is internalized and desensitized upon protein kinase C activation. | Mathiesen, JM. and Ramirez, MT. 2006. Br J Pharmacol. 148: 279-90. PMID: 16582932
- Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 4. | Flor, PJ., et al. 1995. Neuropharmacology. 34: 149-55. PMID: 7617140
- Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. | Wu, S., et al. 1998. Brain Res Mol Brain Res. 53: 88-97. PMID: 9473604
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
mGluR-4 Antibody (B-8) | sc-376485 | 200 µg/ml | $322.00 | |||
mGluR-4 Antibody (B-8): m-IgGκ BP-HRP Bundle | sc-522970 | 200 µg Ab, 40 µg BP | $361.00 | |||
mGluR-4 Antibody (B-8): m-IgG2a BP-HRP Bundle | sc-546128 | 200 µg Ab; 10 µg BP | $361.00 | |||
mGluR-4 Antibody (B-8) AC | sc-376485 AC | 500 µg/ml, 25% agarose | $424.00 | |||
mGluR-4 Antibody (B-8) HRP | sc-376485 HRP | 200 µg/ml | $322.00 | |||
mGluR-4 Antibody (B-8) FITC | sc-376485 FITC | 200 µg/ml | $336.00 | |||
mGluR-4 Antibody (B-8) PE | sc-376485 PE | 200 µg/ml | $349.00 | |||
mGluR-4 Antibody (B-8) Alexa Fluor® 488 | sc-376485 AF488 | 200 µg/ml | $364.00 | |||
mGluR-4 Antibody (B-8) Alexa Fluor® 546 | sc-376485 AF546 | 200 µg/ml | $364.00 | |||
mGluR-4 Antibody (B-8) Alexa Fluor® 594 | sc-376485 AF594 | 200 µg/ml | $364.00 | |||
mGluR-4 Antibody (B-8) Alexa Fluor® 647 | sc-376485 AF647 | 200 µg/ml | $364.00 | |||
mGluR-4 Antibody (B-8) Alexa Fluor® 680 | sc-376485 AF680 | 200 µg/ml | $364.00 | |||
mGluR-4 Antibody (B-8) Alexa Fluor® 790 | sc-376485 AF790 | 200 µg/ml | $364.00 |