Mfn2/Mitofusin 2 Antibody (F-5): sc-515647

Mfn2 Antibody (F-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects Mfn2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Mfn2 (F-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Mfn2 protein, also known as mitochondrial fusion 2, plays a critical role in mitochondrial dynamics by mediating the fusion of mitochondria, which is essential for maintaining mitochondrial function and cellular energy homeostasis. This process is particularly important in tissues with high energy demands, such as heart and muscle, where Mfn2 is abundantly expressed. Proper functioning of Mfn2 is crucial for embryonic development and has been implicated in the pathobiology of various metabolic disorders, including obesity. Notably, Mfn2 interacts with other proteins involved in mitochondrial dynamics, such as Mfn1, and these interactions are vital for the formation of mitochondrial networks that support cellular metabolism. Understanding the role of Mfn2 and its interactions can provide insights into mitochondrial-related diseases and potential therapeutic targets.

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Mfn2/Mitofusin 2 Antibody (F-5) References:

1. Targeting mitochondrial dynamics by regulating Mfn2 for therapeutic intervention in diabetic cardiomyopathy.  |  Hu, L., et al. 2019. Theranostics. 9: 3687-3706. PMID: 31281507
2. Mfn2 Regulates High Glucose-Induced MAMs Dysfunction and Apoptosis in Podocytes via PERK Pathway.  |  Cao, Y., et al. 2021. Front Cell Dev Biol. 9: 769213. PMID: 34988075
3. Mfn2-mediated mitochondrial fusion alleviates doxorubicin-induced cardiotoxicity with enhancing its anticancer activity through metabolic switch.  |  Ding, M., et al. 2022. Redox Biol. 52: 102311. PMID: 35413642
4. Paeonol protects against doxorubicin-induced cardiotoxicity by promoting Mfn2-mediated mitochondrial fusion through activating the PKCε-Stat3 pathway.  |  Ding, M., et al. 2023. J Adv Res. 47: 151-162. PMID: 35842187
5. Mfn2-mediated mitochondrial fusion promotes autophagy and suppresses ovarian cancer progression by reducing ROS through AMPK/mTOR/ERK signaling.  |  Ashraf, R. and Kumar, S. 2022. Cell Mol Life Sci. 79: 573. PMID: 36308626
6. Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy.  |  Yang, L., et al. 2023. J Neuroinflammation. 20: 31. PMID: 36765376
7. MFN2 suppresses clear cell renal cell carcinoma progression by modulating mitochondria-dependent dephosphorylation of EGFR.  |  Luo, L., et al. 2023. Cancer Commun (Lond). 43: 808-833. PMID: 37378422
8. PGAM5 is an MFN2 phosphatase that plays an essential role in the regulation of mitochondrial dynamics.  |  Nag, S., et al. 2023. Cell Rep. 42: 112895. PMID: 37498743
9. LRRK2 aggravates kidney injury through promoting MFN2 degradation and abnormal mitochondrial integrity.  |  Zhang, S., et al. 2023. Redox Biol. 66: 102860. PMID: 37633049
10. Mfn2/Hsc70 Complex Mediates the Formation of Mitochondria-Lipid Droplets Membrane Contact and Regulates Myocardial Lipid Metabolism.  |  Hu, L., et al. 2024. Adv Sci (Weinh). 11: e2307749. PMID: 38311582

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Mfn2/Mitofusin 2 Antibody (F-5) has 53 citations in a variety of scientific publications.

Primary antibodies like Anti-Mfn2/Mitofusin 2 Antibody (F-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Mfn2/Mitofusin 2 Antibody (F-5) Specifications

Alternate Product Name: Mitofusin-2

Product Clone Name: F-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 461-528

Epitope Target: Mfn2

Epitope Species: human

Product Reactivity/Detection: Mfn2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 53 citations in various scientific publications

Available Conjugates/Forms for Mfn2/Mitofusin 2 Antibody (F-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Mfn2/Mitofusin 2 antibody is Mfn2/Mitofusin 2 Antibody (XX-1): sc-100560.