MFAP4 Antibody (A-9): sc-398438
- MFAP4 Antibody (A-9) is a mouse monoclonal IgG2b κ MFAP4 antibody, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 19-38 near the N-terminus of MFAP4 of human origin
- MFAP4 Antibody (A-9) is recommended for detection of MFAP4 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MFAP4 Antibody (A-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MFAP4 Antibody (A-9) for WB applications. These reagents are now offered in bundles with MFAP4 Antibody (A-9) (see ordering information below).
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MFAP4 Antibody (A-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects MFAP4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MFAP4 (A-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MFAP4 protein plays a crucial role in the formation and stabilization of microfibrils, which are essential components of the extracellular matrix that provide structural support to tissues. These microfibrils can interact with elastin, influencing the mechanical properties of connective tissues. Proper functioning of MFAP4 is vital for maintaining the integrity of the extracellular matrix, and MFAP4 dysregulation has been implicated in various congenital disorders, including Smith-Magenis syndrome, where deletion of the MFAP4 gene has been observed in a significant number of patients. Understanding MFAP4′s role in microfibril assembly and interactions with other extracellular matrix components is important for elucidating the molecular mechanisms underlying connective tissue disorders and developing potential therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MFAP4 Antibody (A-9) References:
- Microfibril-associated protein 4 is present in lung washings and binds to the collagen region of lung surfactant protein D. | Lausen, M., et al. 1999. J Biol Chem. 274: 32234-40. PMID: 10542261
- Microfibril-associated protein 4 binds to surfactant protein A (SP-A) and colocalizes with SP-A in the extracellular matrix of the lung. | Schlosser, A., et al. 2006. Scand J Immunol. 64: 104-16. PMID: 16867155
- Differential gene expression of 36-kDa microfibril-associated glycoprotein (MAGP-36/MFAP4) in rat organs. | Toyoshima, T., et al. 2008. Cell Tissue Res. 332: 271-8. PMID: 18322703
- Drosophila MFAP1 is required for pre-mRNA processing and G2/M progression. | Andersen, DS. and Tapon, N. 2008. J Biol Chem. 283: 31256-67. PMID: 18765666
- The gene for a human microfibril-associated glycoprotein is commonly deleted in Smith-Magenis syndrome patients. | Zhao, Z., et al. 1995. Hum Mol Genet. 4: 589-97. PMID: 7633408
- Molecular cloning of the microfibrillar protein MFAP3 and assignment of the gene to human chromosome 5q32-q33.2. | Abrams, WR., et al. 1995. Genomics. 26: 47-54. PMID: 7782085
- Structure of the human gene encoding the associated microfibrillar protein (MFAP1) and localization to chromosome 15q15-q21. | Yeh, H., et al. 1994. Genomics. 23: 443-9. PMID: 7835894
- The gene for microfibril-associated protein-1 (MFAP1) is located several megabases centromeric to FBN1 and is not mutated in Marfan syndrome. | Liu, W., et al. 1997. Hum Genet. 99: 578-84. PMID: 9150721
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MFAP4 Antibody (A-9) | sc-398438 | 200 µg/ml | $322.00 | |||
MFAP4 Antibody (A-9): m-IgG Fc BP-HRP Bundle | sc-530799 | 200 µg Ab; 10 µg BP | $361.00 | |||
MFAP4 Antibody (A-9): m-IgGκ BP-HRP Bundle | sc-524342 | 200 µg Ab, 40 µg BP | $361.00 | |||
MFAP4 Antibody (A-9): m-IgG2b BP-HRP Bundle | sc-550228 | 200 µg Ab; 10 µg BP | $361.00 | |||
MFAP4 Antibody (A-9) AC | sc-398438 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MFAP4 Antibody (A-9) HRP | sc-398438 HRP | 200 µg/ml | $322.00 | |||
MFAP4 Antibody (A-9) FITC | sc-398438 FITC | 200 µg/ml | $336.00 | |||
MFAP4 Antibody (A-9) PE | sc-398438 PE | 200 µg/ml | $349.00 | |||
MFAP4 Antibody (A-9) Alexa Fluor® 488 | sc-398438 AF488 | 200 µg/ml | $364.00 | |||
MFAP4 Antibody (A-9) Alexa Fluor® 546 | sc-398438 AF546 | 200 µg/ml | $364.00 | |||
MFAP4 Antibody (A-9) Alexa Fluor® 594 | sc-398438 AF594 | 200 µg/ml | $364.00 | |||
MFAP4 Antibody (A-9) Alexa Fluor® 647 | sc-398438 AF647 | 200 µg/ml | $364.00 | |||
MFAP4 Antibody (A-9) Alexa Fluor® 680 | sc-398438 AF680 | 200 µg/ml | $364.00 | |||
MFAP4 Antibody (A-9) Alexa Fluor® 790 | sc-398438 AF790 | 200 µg/ml | $364.00 | |||
MFAP4 (A-9) Neutralizing Peptide | sc-398438 P | 100 µg/0.5 ml | $69.00 |