Met Antibody (D-4): sc-514148

Met Antibody (D-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Met protein of human origin through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Met (D-4) antibody is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, offering versatility for different experimental needs. Met protein, a transmembrane receptor with intrinsic tyrosine kinase activity, plays a crucial role in cellular processes such as proliferation, survival, and migration, making Met (D-4) monoclonal antibody valuable in cancer biology and tissue regeneration research. Met protein is primarily located on the cell surface, where Met protein interacts with hepatocyte growth factor, a key regulator of liver regeneration and tissue repair. Dysregulation of Met signaling has been implicated in various malignancies, as overexpression of the c-Met oncogene is frequently observed in tumors, leading to enhanced tumor growth and metastasis. Understanding Met protein function and regulation is essential for developing targeted therapies in cancer treatment, highlighting anti-Met antibody (D-4) significance in research and clinical applications.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Met Antibody (D-4) has 20 citations in a variety of scientific publications.

Primary antibodies like Anti-Met Antibody (D-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Met Antibody (D-4) Specifications

Alternate Product Name: c-Met

Product Clone Name: D-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1375-1391

Epitope Target: Met

Epitope Species: human

Product Reactivity/Detection: Met

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 20 citations in various scientific publications

Available Conjugates/Forms for Met Antibody (D-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred Met antibody is Met Antibody (B-2): sc-8057.