Menin Antibody (E-9): sc-390345

Menin Antibody (E-9) is a mouse monoclonal IgG1 antibody that detects menin in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Menin, a crucial nuclear tumor suppressor, plays a significant role in regulating gene transcription through covalent histone modifications, which is vital for maintaining cellular differentiation and preventing tumorigenesis. Menin′s interaction with the TGFβeta/Smad3 signaling pathway in osteoblasts is particularly important, as menin negatively regulates the transcriptional activities of BMP2/Smad1/5 and Runx2, thereby inhibiting late-stage differentiation. This regulatory function underscores menin′s importance in bone development and potential implications in diseases such as multiple endocrine neoplasia type I (MEN1), where mutations in the menin gene lead to tumor formation. Additionally, menin influences the expression of insulin-like growth factor binding protein 2 (IGFBP-2) by modulating its promoter, further highlighting menin′s role in cellular growth and metabolism. The existence of multiple mRNA variants, including those resulting from alternative splicing, adds complexity to menin′s function and regulation, making anti-menin antibody (E-9) an essential tool for researchers studying menin′s diverse biological roles and implications in health and disease.

The preferred Menin antibody is Menin Antibody (B-9): sc-374371.