Menin Antibody (E-8): sc-376596

Menin Antibody (E-8) is a mouse monoclonal IgG1 antibody that detects menin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Menin is a crucial nuclear tumor suppressor that plays a significant role in regulating gene expression and cellular differentiation, particularly in the context of multiple endocrine neoplasia type I (MEN1), where mutations in the menin gene are implicated. Menin is primarily located in the nucleus, where anti-menin antibody (E-8) can detect interactions with various transcription factors and chromatin-modifying complexes that influence the transcription of genes involved in cell growth and differentiation. This nuclear localization is vital as menin exerts tumor-suppressive effects by modulating the expression of genes that control cellular proliferation and apoptosis. Notably, menin′s interaction with the TGFβeta/Smad3 signaling pathway in osteoblasts highlights menin′s importance in bone development and homeostasis, as menin negatively regulates the transcriptional activities of key factors like BMP2 and Runx2, which are essential for late-stage differentiation. Menin (E-8) antibody is an invaluable tool for researchers studying the molecular mechanisms underlying MEN1 and related disorders, providing insights into the functional dynamics of menin.

The preferred Menin antibody is Menin Antibody (B-9): sc-374371.