MEL-1A-R Antibody (B-10): sc-390328

MEL-1A-R Antibody (B-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects MEL-1A-R protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MEL-1A-R (B-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MEL-1A-R, also known as Melatonin Receptor 1A, plays a crucial role in mediating melatonin effects, a hormone secreted by the pineal gland that regulates circadian rhythms and reproductive functions. MEL-1A-R is primarily located on the cell membrane and belongs to the super-family of guanine nucleotide-binding regulatory protein (G protein)-coupled receptors. This strategic location enables rapid transmission of melatonin signals into the cell, influencing various physiological processes such as sleep-wake cycles and seasonal reproductive changes. MEL-1A-R activation leads to adenylate cyclase inhibition and phospholipase Cb stimulation, essential for downstream signaling pathways affecting cellular growth and differentiation. MEL-1A-R′s role in these processes helps understand potential implications in tumorigenesis and other melatonin-related disorders.

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MEL-1A-R Antibody (B-10) References:

1. Tight association of the human Mel(1a)-melatonin receptor and G(i): precoupling and constitutive activity.  |  Roka, F., et al. 1999. Mol Pharmacol. 56: 1014-24. PMID: 10531408
2. Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins.  |  Brydon, L., et al. 1999. Mol Endocrinol. 13: 2025-38. PMID: 10598579
3. Melatonin receptors in human uveal melanocytes and melanoma cells.  |  Roberts, JE., et al. 2000. J Pineal Res. 28: 165-71. PMID: 10739303
4. Melatonin and mammary pathological growth.  |  Cos, S. and Sánchez-Barceló, EJ. 2000. Front Neuroendocrinol. 21: 133-70. PMID: 10764528
5. Melatonin and sex hormone interrelationships--a review.  |  Luboshitzky, R. and Lavie, P. 1999. J Pediatr Endocrinol Metab. 12: 355-62. PMID: 10821215
6. Biological basis and possible physiological implications of melatonin receptor-mediated signaling in the rat epididymis.  |  Shiu, SY., et al. 2000. Biol Signals Recept. 9: 172-87. PMID: 10899702
7. Melatonin and biological rhythms.  |  Pévet, P. 2000. Biol Signals Recept. 9: 203-12. PMID: 10899705
8. Melatonin receptor 1A gene polymorphism associated with polycystic ovary syndrome.  |  Li, C., et al. 2011. Gynecol Obstet Invest. 72: 130-4. PMID: 21474908
9. Role of melatonin receptor 1A and pituitary homeobox-1 coexpression in protecting tubular epithelial cells in membranous nephropathy.  |  Huang, YS., et al. 2018. J Pineal Res. 65: e12482. PMID: 29480949
10. Melatonin receptor 1A, but not 1B, knockout decreases biliary damage and liver fibrosis during cholestatic liver injury.  |  Wu, N., et al. 2022. Hepatology. 75: 797-813. PMID: 34743371
11. Long-term environmental exposure of darkness induces hyperandrogenism in PCOS via melatonin receptor 1A and aromatase reduction.  |  Chu, W., et al. 2022. Front Cell Dev Biol. 10: 954186. PMID: 36353509
12. Melatonin receptor 1A variants as genetic cause of idiopathic osteoporosis.  |  Bisikirska, B., et al. 2024. Sci Transl Med. 16: eadj0085. PMID: 39413162

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MEL-1A-R Antibody (B-10) has 17 citations in a variety of scientific publications.

Primary antibodies like Anti-MEL-1A-R Antibody (B-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MEL-1A-R Antibody (B-10) Specifications

Alternate Product Name: MTNR1A

Product Clone Name: B-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 7-26

Epitope Target: MEL-1A-R

Epitope Species: human

Product Reactivity/Detection: MEL-1A-R

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 17 citations in various scientific publications

Available Conjugates/Forms for MEL-1A-R Antibody (B-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred MEL-1A/B-R antibody is MEL-1A/B-R Antibody (B-8): sc-398788.