MEK-7 Antibody (E-7): sc-25288

MEK-7 Antibody (E-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects MEK-7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-MEK-7 antibody (E-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MEK-7, also known as MKK-7, plays a crucial role in activating the c-Jun N-terminal kinase (JNK) signaling pathway, which regulates cellular responses to stress, inflammation, and apoptosis. MEK-7-mediated JNK activation is particularly important in various physiological and pathological processes, including cell differentiation, survival, and response to environmental stimuli. Understanding MEK-7 function and JNK activation can provide valuable insights into mechanisms underlying diseases such as cancer and neurodegenerative disorders, making MEK-7 (E-7) monoclonal antibody a vital tool for researchers studying these critical pathways.

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MEK-7 Antibody (E-7) References:

1. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product.  |  Crews, CM., et al. 1992. Science. 258: 478-80. PMID: 1411546
2. MKK7, the essential regulator of JNK signaling involved in cancer cell survival: a newly emerging anticancer therapeutic target.  |  Park, JG., et al. 2019. Ther Adv Med Oncol. 11: 1758835919875574. PMID: 31579105
3. MKK7 deficiency in mature neurons impairs parental behavior in mice.  |  Shin, T., et al. 2021. Genes Cells. 26: 5-17. PMID: 33098150
4. Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries.  |  Gehrtz, P., et al. 2022. J Med Chem. 65: 10341-10356. PMID: 35912476
5. Components of a new human protein kinase signal transduction pathway.  |  Zhou, G., et al. 1995. J Biol Chem. 270: 12665-9. PMID: 7759517
6. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms.  |  Dérijard, B., et al. 1995. Science. 267: 682-5. PMID: 7839144
7. Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.  |  Wu, J., et al. 1993. Mol Cell Biol. 13: 4539-48. PMID: 8393135
8. Characterization of the structure and function of a novel MAP kinase kinase (MKK6).  |  Han, J., et al. 1996. J Biol Chem. 271: 2886-91. PMID: 8621675
9. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta).  |  Jiang, Y., et al. 1996. J Biol Chem. 271: 17920-6. PMID: 8663524
10. Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase.  |  Tournier, C., et al. 1997. Proc Natl Acad Sci U S A. 94: 7337-42. PMID: 9207092
11. MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous.  |  Holland, PM., et al. 1997. J Biol Chem. 272: 24994-8. PMID: 9312105
12. Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase.  |  Wu, Z., et al. 1997. Mol Cell Biol. 17: 7407-16. PMID: 9372971

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MEK-7 Antibody (E-7) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-MEK-7 Antibody (E-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MEK-7 Antibody (E-7) Specifications

Alternate Product Name: MEK-7

Product Clone Name: E-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-160

Epitope Target: MEK-7

Epitope Species: human

Product Reactivity/Detection: MEK-7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for MEK-7 Antibody (E-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin