MD-1 Antibody (H-12): sc-393238
- MD-1 Antibody (H-12) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 24-51 near the N-terminus of MD-1 of human origin
- recommended for detection of MD-1 of human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG3 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MD-1 Antibody (H-12) for WB and IHC(P) applications. These reagents are now offered in bundles with MD-1 Antibody (H-12) (see ordering information below).
MD-1 Antibody (H-12) is a mouse monoclonal IgG3 antibody that detects MD-1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MD-1 plays a crucial role in the immune response by forming a complex with RP105, which is essential for proper B cell signaling in response to lipopolysaccharides (LPS). This interaction enhances B cell activation and proliferation, particularly during immune challenges. MD-1 is primarily located on the surface of B cells, monocytes, and tonsils, where MD-1 facilitates cell surface expression of RP105 despite lacking a transmembrane region. This unique localization allows MD-1 to effectively participate in the LPS-signaling complex, thereby amplifying immune response. MD-1 contains two N-glycosylation sites, which are important for stability and function, ensuring adequate support of immune signaling pathways necessary for robust defense against pathogens. Anti-MD-1 antibody (H-12) serves as an invaluable tool for researchers studying B cell activation and immune signaling mechanisms.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MD-1 Antibody (H-12) | sc-393238 | 200 µg/ml | $322.00 | |||
MD-1 Antibody (H-12): m-IgGκ BP-HRP Bundle | sc-535734 | 200 µg Ab; 40 µg BP | $361.00 | |||
MD-1 Antibody (H-12): m-IgG3 BP-HRP Bundle | sc-550310 | 200 µg Ab; 40 µg BP | $361.00 | |||
MD-1 (H-12) Neutralizing Peptide | sc-393238 P | 100 µg/0.5 ml | $69.00 |