MCT4 Antibody (F-10): sc-376101

MCT4 Antibody (F-10) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect Monocarboxylate Transporter 4 (MCT4) across mouse, rat, and human species using various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-MCT4 antibody (F-10) targets amino acids 376-465 within the C-terminal cytoplasmic domain of human MCT4, ensuring precise binding and reliable results. MCT4 is a member of the solute carrier 16A (SLC16A) family of proteins, and plays a critical role in cellular metabolism by facilitating the transport of lactate and other monocarboxylates out of cells, which is essential for maintaining intracellular pH and allowing continued glycolysis, especially under anaerobic conditions. This function is particularly important in highly glycolytic tissues such as skeletal muscle and in tumor cells, where MCT4 helps manage increased lactate production associated with the Warburg effect, thereby supporting rapid cell proliferation and survival in hypoxic environments. By effectively exporting lactate, MCT4 contributes to metabolic flexibility of cancer cells, making MCT4 a key target for cancer research and potential therapeutic interventions. Anti-MCT4 antibody (F-10) is available in non-conjugated form as well as various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatile options for diverse experimental needs. MCT4 monoclonal antibody (F-10) is an invaluable tool for researchers studying metabolic pathways involving MCT4, disease progression, and potential biomarker or therapeutic applications.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MCT4 Antibody (F-10) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-MCT4 Antibody (F-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MCT4 Antibody (F-10) Specifications

Alternate Product Name: SLC16A3

Product Clone Name: F-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 376-465

Epitope Target: MCT4

Epitope Species: human

Product Reactivity/Detection: MCT4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for MCT4 Antibody (F-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred MCT4 antibody is MCT4 Antibody (D-1): sc-376140.