MCT4 Inhibitors

Common MCT4 Inhibitors include, but are not limited to AR-C155858 CAS 496791-37-8, Sodium dichloroacetate CAS 2156-56-1, 1,1-Dimethylbiguanide, Hydrochloride CAS 1115-70-4, 2-Deoxy-D-glucose CAS 154-17-6 and Phenformin Hydrochloride CAS 834-28-6.

Monocarboxylate transporter 4 (MCT4) is a member of the monocarboxylate transporter family, which is responsible for the transport of monocarboxylates, such as lactate and pyruvate, across cell membranes. These transporters play a crucial role in metabolic processes, particularly in cells that undergo glycolysis at a high rate and produce an abundance of lactate as a byproduct. MCT4 is distinctively expressed in cells and tissues that have high glycolytic rates and is pivotal in facilitating the efflux of lactate out of these cells. In doing so, MCT4 ensures that the intracellular environment remains conducive to continuous glycolytic activity by preventing the accumulation of excess lactate which could impede the glycolytic pathway.

MCT4 inhibitors are chemical compounds designed to specifically impede the function of MCT4. By inhibiting MCT4, these molecules can modulate the intracellular and extracellular concentrations of lactate and other monocarboxylates, affecting the metabolic dynamics of the cell. The interaction between MCT4 inhibitors and the transporter can be achieved through various mechanisms, including direct binding to the transporter, altering its conformation, or competing with its natural substrates.