MCT2 Antibody (B-10): sc-271093
- MCT2 Antibody (B-10) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 391-480 mapping at the C-terminus of MCT2 of mouse origin
- recommended for detection of MCT2 of mouse origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for MCT2 Antibody (B-10) for WB applications. This reagent is now offered in a bundle with MCT2 Antibody (B-10) (see ordering information below).
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MCT2 Antibody (B-10) is a mouse monoclonal IgG1 light chain antibody that detects MCT2 in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MCT2, a member of the monocarboxylate transporter family, plays a crucial role in the transport of lactate and other monocarboxylates across cell membranes, which is vital for maintaining cellular energy homeostasis. MCT2 is predominantly expressed in the liver and testis, where MCT2 facilitates the uptake of lactate produced during glycolysis, thereby supporting metabolic processes essential for energy production and cellular function. The proper functioning of MCT2 is particularly important in tissues with high metabolic demands, as MCT2 helps regulate the intracellular concentration of lactate and prevents acidosis, which can impair cellular activities. Anti-MCT2 antibody (B-10) is an invaluable tool for researchers studying metabolic pathways, cellular respiration, and the physiological roles of lactate transport in various biological contexts.
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MCT2 Antibody (B-10) References:
- MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brain. | Pierre, K., et al. 2002. J Cereb Blood Flow Metab. 22: 586-95. PMID: 11973431
- Developmental and hormonal regulation of the monocarboxylate transporter 2 (MCT2) expression in the mouse germ cells. | Boussouar, F., et al. 2003. Biol Reprod. 69: 1069-78. PMID: 12773420
- Noradrenaline enhances monocarboxylate transporter 2 expression in cultured mouse cortical neurons via a translational regulation. | Pierre, K., et al. 2003. J Neurochem. 86: 1468-76. PMID: 12950455
- The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein. | Ovens, MJ., et al. 2010. Biochem J. 431: 217-25. PMID: 20695846
- Redistribution of monocarboxylate transporter 2 on the surface of astrocytes in the human epileptogenic hippocampus. | Lauritzen, F., et al. 2012. Glia. 60: 1172-81. PMID: 22535546
- The distribution and density of monocarboxylate transporter 2 in cerebral cortex, hippocampus and cerebellum of wild-type mice. | Pang, R., et al. 2020. J Anat. 236: 370-377. PMID: 31713246
- Targeting the monocarboxylate transporter MCT2 and lactate dehydrogenase A LDHA in cancer cells with FX-11 and AR-C155858 inhibitors. | Alobaidi, B., et al. 2023. Eur Rev Med Pharmacol Sci. 27: 6605-6617. PMID: 37522672
- Hippocampal Lactate-Infusion Enhances Spatial Memory Correlated with Monocarboxylate Transporter 2 and Lactylation. | Wu, Y., et al. 2024. Brain Sci. 14: PMID: 38671979
- Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-transcriptional regulation. | Jackson, VN., et al. 1997. Biochem J. 324 (Pt 2): 447-53. PMID: 9182702
- Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. | Lin, RY., et al. 1998. J Biol Chem. 273: 28959-65. PMID: 9786900
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MCT2 Antibody (B-10) | sc-271093 | 200 µg/ml | $322.00 | |||
MCT2 Antibody (B-10): m-IgG Fc BP-HRP Bundle | sc-540201 | 200 µg Ab; 10 µg BP | $361.00 |