MCT11 Antibody (G-4): sc-515145
- MCT11 Antibody (G-4) is a mouse monoclonal IgG2a κ MCT11 antibody provided at 200 µg/ml
- raised against amino acids 263-309 mapping within an internal region of MCT11 of human origin
- MCT11 Antibody (G-4) is recommended for detection of MCT11 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MCT11 Antibody (G-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MCT11 Antibody (G-4) for WB applications. These reagents are now offered in bundles with MCT11 Antibody (G-4) (see ordering information below).
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MCT11 Antibody (G-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects MCT11 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MCT11 (G-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MCT11, also known as SLC16A11, is a member of the monocarboxylate transporter family, which plays a crucial role in cellular metabolism by facilitating the transport of monocarboxylates such as lactate and pyruvate across the plasma membrane. This transport is vital for maintaining cellular energy levels, particularly during anaerobic respiration when lactic acid accumulates as a byproduct of glycolysis. MCT11 is characterized by its 10-12 transmembrane helical domains, with both the amino and carboxy termini located in the cytoplasm, allowing MCT11 to function effectively as a proton-linked transporter. By regulating lactate levels within the cell, MCT11 helps prevent a drop in intracellular pH, thereby ensuring that glycolysis can continue efficiently, which is essential for ATP production and overall cellular function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MCT11 Antibody (G-4) References:
- Lactate transport in skeletal muscle - role and regulation of the monocarboxylate transporter. | Juel, C. and Halestrap, AP. 1999. J Physiol. 517 (Pt 3): 633-42. PMID: 10358105
- The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. | Halestrap, AP. and Price, NT. 1999. Biochem J. 343 Pt 2: 281-99. PMID: 10510291
- The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. | Halestrap, AP. and Meredith, D. 2004. Pflugers Arch. 447: 619-28. PMID: 12739169
- Molecular features, regulation, and function of monocarboxylate transporters: implications for drug delivery. | Enerson, BE. and Drewes, LR. 2003. J Pharm Sci. 92: 1531-44. PMID: 12884241
- Monocarboxylate transporters in the central nervous system: distribution, regulation and function. | Pierre, K. and Pellerin, L. 2005. J Neurochem. 94: 1-14. PMID: 15953344
- Monocarboxylate transporter-mediated transport of gamma-hydroxybutyric acid in human intestinal Caco-2 cells. | Lam, WK., et al. 2010. Drug Metab Dispos. 38: 441-7. PMID: 19952290
- Cellular expression of the monocarboxylate transporter (MCT) family in the placenta of mice. | Nagai, A., et al. 2010. Placenta. 31: 126-33. PMID: 20022372
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MCT11 Antibody (G-4) | sc-515145 | 200 µg/ml | $322.00 | |||
MCT11 Antibody (G-4): m-IgG Fc BP-HRP Bundle | sc-531298 | 200 µg Ab; 10 µg BP | $361.00 | |||
MCT11 Antibody (G-4): m-IgGκ BP-HRP Bundle | sc-524953 | 200 µg Ab, 40 µg BP | $361.00 | |||
MCT11 Antibody (G-4): m-IgG2a BP-HRP Bundle | sc-547755 | 200 µg Ab; 10 µg BP | $361.00 | |||
MCT11 Antibody (G-4) AC | sc-515145 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MCT11 Antibody (G-4) HRP | sc-515145 HRP | 200 µg/ml | $322.00 | |||
MCT11 Antibody (G-4) FITC | sc-515145 FITC | 200 µg/ml | $336.00 | |||
MCT11 Antibody (G-4) PE | sc-515145 PE | 200 µg/ml | $349.00 | |||
MCT11 Antibody (G-4) Alexa Fluor® 488 | sc-515145 AF488 | 200 µg/ml | $364.00 | |||
MCT11 Antibody (G-4) Alexa Fluor® 546 | sc-515145 AF546 | 200 µg/ml | $364.00 | |||
MCT11 Antibody (G-4) Alexa Fluor® 594 | sc-515145 AF594 | 200 µg/ml | $364.00 | |||
MCT11 Antibody (G-4) Alexa Fluor® 647 | sc-515145 AF647 | 200 µg/ml | $364.00 | |||
MCT11 Antibody (G-4) Alexa Fluor® 680 | sc-515145 AF680 | 200 µg/ml | $364.00 | |||
MCT11 Antibody (G-4) Alexa Fluor® 790 | sc-515145 AF790 | 200 µg/ml | $364.00 |