MCP-1 Antibody (D9): sc-32781
- MCP-1 Antibody (D9) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against mouse B cell lymphoma L1.2 transfectants expressing MCP-1 of human origin
- recommended for detection of MCP-1 of human origin by WB and IP
- also provided azide-free for neutralizing, sc-32781 L, 200 µg/0.1 ml
- See MCP-1-4/eotaxin (B-2): sc-377082 for MCP-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MCP-1 Antibody (D9) for WB applications. These reagents are now offered in bundles with MCP-1 Antibody (D9) (see ordering information below).
QUICK LINKS
MCP-1 Antibody (D9) is a mouse monoclonal IgG1 antibody that detects MCP-1 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). MCP-1, also known as CCL2, plays a crucial role in the immune response by mediating the recruitment of monocytes to sites of inflammation, which is vital for effective immune surveillance and tissue repair. This chemokine is primarily produced by activated T lymphocytes and various other cell types in response to pro-inflammatory cytokines like interleukin-1, tumor necrosis factor-alpha, and interferon-gamma. The ability of MCP-1 to attract monocytes is particularly important during infection and inflammatory processes, as it facilitates the accumulation of immune cells at the site of injury or infection, thereby enhancing the body′s defense mechanisms. Additionally, MCP-1 interacts with two distinct receptors, CCR2 and CCR4, which are involved in different signaling pathways that regulate immune cell migration and activation. Anti-MCP-1 antibody (D9) is an essential tool for researchers studying the dynamics of immune responses and the underlying mechanisms of various inflammatory diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MCP-1 Antibody (D9) References:
- MCP-1 and RANTES are mediators of acute and chronic inflammation. | Conti, P. and DiGioacchino, M. 2001. Allergy Asthma Proc. 22: 133-7. PMID: 11424873
- MCP-1 induces a novel transcription factor with proapoptotic activity. | Bidzhekov, K., et al. 2006. Circ Res. 98: 1107-9. PMID: 16690887
- MCP-1/CCL2 as a therapeutic target in myocardial infarction and ischemic cardiomyopathy. | Xia, Y. and Frangogiannis, NG. 2007. Inflamm Allergy Drug Targets. 6: 101-7. PMID: 17692033
- Role of MCP-1 and CCR2 in alcohol neurotoxicity. | Zhang, K. and Luo, J. 2019. Pharmacol Res. 139: 360-366. PMID: 30472461
- MCP-1 Predicts Recurrent Cardiovascular Events in Patients with Persistent Inflammation. | Blanco-Colio, LM., et al. 2021. J Clin Med. 10: PMID: 33803115
- Plasma MCP-1 and changes on cognitive function in community-dwelling older adults. | Sanchez-Sanchez, JL., et al. 2022. Alzheimers Res Ther. 14: 5. PMID: 34996522
- MCP-1 facilitates VEGF production by removing miR-374b-5p blocking of VEGF mRNA translation. | Zhao, HY., et al. 2022. Biochem Pharmacol. 206: 115334. PMID: 36328133
- MCP-1 expression in breast cancer and its association with distant relapse. | Mulholland, BS., et al. 2023. Cancer Med. 12: 16221-16230. PMID: 37341066
- MCP-1 controls IL-17-promoted monocyte migration and M1 polarization in osteoarthritis. | Hsieh, SL., et al. 2024. Int Immunopharmacol. 132: 112016. PMID: 38593506
- MCP-1 exerts the inflammatory response via ILK activation during endometriosis pathogenesis. | Soni, UK., et al. 2024. Life Sci. 353: 122902. PMID: 39004271
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MCP-1 Antibody (D9) | sc-32781 | 200 µg/ml | $322.00 | |||
MCP-1 Antibody (D9): m-IgG Fc BP-HRP Bundle | sc-538925 | 200 µg Ab; 10 µg BP | $361.00 | |||
MCP-1 Antibody (D9): m-IgG1 BP-HRP Bundle | sc-541155 | 200 µg Ab; 20 µg BP | $361.00 | |||
MCP-1 Antibody (D9) L | sc-32781 L | 200 µg/0.1 ml | $322.00 |