MCP-1 Antibody (1A7B8): sc-32819
- MCP-1 Antibody (1A7B8) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against recombinant human MCP-1
- recommended for detection of MCP-1 of human origin by WB, IP, IF and IHC(P)
- See MCP-1-4/eotaxin (B-2): sc-377082 for MCP-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MCP-1 Antibody (1A7B8) for WB and IHC(P) applications. These reagents are now offered in bundles with MCP-1 Antibody (1A7B8) (see ordering information below).
QUICK LINKS
MCP-1 Antibody (1A7B8) is a mouse monoclonal IgG1 antibody that detects MCP-1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. MCP-1, also known as CCL2, plays a crucial role in the immune response by mediating the recruitment of monocytes to sites of inflammation, which is vital for effective immune surveillance and tissue repair. This chemokine is primarily secreted by activated T lymphocytes and other immune cells in response to pro-inflammatory cytokines such as interleukin-1, tumor necrosis factor-alpha, and interferon-gamma. The ability of MCP-1 to attract monocytes is particularly important during infection and inflammatory processes, as it facilitates the accumulation of leukocytes at the site of injury or infection, thereby enhancing the body′s defense mechanisms. Additionally, MCP-1 interacts with two distinct receptors, CCR2 and CCR4, which are involved in mediating its effects on various immune cell types. Anti-MCP-1 antibody (1A7B8) is an essential tool for researchers studying the dynamics of immune responses and the role of chemokines in various pathological conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MCP-1 Antibody (1A7B8) References:
- Role of MCP-1 in cardiovascular disease: molecular mechanisms and clinical implications. | Niu, J. and Kolattukudy, PE. 2009. Clin Sci (Lond). 117: 95-109. PMID: 19566488
- Urinary MCP-1/creatinine in Henoch-Schönlein purpura and its relationship with nephritis. | Fuentes, Y., et al. 2014. Pediatr Nephrol. 29: 1047-52. PMID: 24414608
- ICAM-1 regulates macrophage polarization by suppressing MCP-1 expression via miR-124 upregulation. | Gu, W., et al. 2017. Oncotarget. 8: 111882-111901. PMID: 29340098
- Ultravist Induces the Expression of MCP-1 and VCAM-1 in IL-4-Stimulated HUVECs. | Kim, HL., et al. 2019. Biol Pharm Bull. 42: 915-922. PMID: 30918133
- MCP-1 deficiency enhances browning of adipose tissue via increased M2 polarization. | Rajasekaran, M., et al. 2019. J Endocrinol. 242: 91-101. PMID: 31137011
- The MCP-1 rs1024611 and MTHFR rs1801133 gene variations and expressions in alopecia areata: A pilot study. | Tabatabaei-Panah, PS., et al. 2022. Immun Inflamm Dis. 10: 209-217. PMID: 34752683
- IL-17 upregulates MCP-1 expression via Act1 / TRAF6 / TAK1 in experimental autoimmune myocarditis. | Huang, X., et al. 2022. Cytokine. 152: 155823. PMID: 35183823
- Mammalian Glycosylation Patterns Protect Citrullinated Chemokine MCP-1/CCL2 from Partial Degradation. | Korchynskyi, O., et al. 2023. Int J Mol Sci. 24: PMID: 36768186
- Plasma CXCL8 and MCP-1 as biomarkers of latent tuberculosis infection. | Selvavinayagam, ST., et al. 2023. medRxiv.. PMID: 37609153
- MCP-1 and CCR2 in HIV infection: regulation of agonist and receptor expression. | Sozzani, S., et al. 1997. J Leukoc Biol. 62: 30-3. PMID: 9225989
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MCP-1 Antibody (1A7B8) | sc-32819 | 200 µg/ml | $322.00 | |||
MCP-1 Antibody (1A7B8): m-IgG Fc BP-HRP Bundle | sc-538926 | 200 µg Ab; 10 µg BP | $361.00 | |||
MCP-1 Antibody (1A7B8): m-IgG1 BP-HRP Bundle | sc-541156 | 200 µg Ab; 20 µg BP | $361.00 |