MBNL1 Antibody (4A8): sc-136165
- MBNL1 Antibody (4A8) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against full-length recombinant MBNL1 of human origin
- recommended for detection of MBNL1 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See MBNL1 (3A4): sc-47740 for MBNL1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MBNL1 Antibody (4A8) for WB and IHC(P) applications. These reagents are now offered in bundles with MBNL1 Antibody (4A8) (see ordering information below).
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MBNL1 Antibody (4A8) is a mouse monoclonal IgG1 antibody that detects MBNL1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. MBNL1 is a crucial protein involved in the regulation of pre-mRNA splicing, a vital process that influences gene expression and cellular function. This 370 amino acid protein is predominantly expressed in various tissues, including skeletal muscle, prostate, lung, heart, small intestine, ovary, and placenta, highlighting its significance in both normal physiology and disease states. Notably, MBNL1 interacts with expanded CUG repeats, which are implicated in myotonic dystrophy types 1 and 2 (DM1 and DM2). The localization of MBNL1 to nuclear foci in these disorders suggests that the accumulation of mutant RNA is pathogenic, thereby linking MBNL1 to the underlying mechanisms of these diseases. Anti-MBNL1 antibody (4A8) effectively detects this target across multiple applications, making MBNL1 (4A8) antibody an invaluable tool for researchers studying the complexities of gene regulation and the molecular basis of myotonic dystrophies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MBNL1 Antibody (4A8) References:
- MBNL1-mediated regulation of differentiation RNAs promotes myofibroblast transformation and the fibrotic response. | Davis, J., et al. 2015. Nat Commun. 6: 10084. PMID: 26670661
- Alternatively spliced MBNL1 isoforms exhibit differential influence on enhancing brown adipogenesis. | Hung, CS. and Lin, JC. 2020. Biochim Biophys Acta Gene Regul Mech. 1863: 194437. PMID: 31730826
- LncRNA MBNL1-AS1 represses gastric cancer progression via the TGF-β pathway by modulating miR-424-5p/Smad7 axis. | Su, J., et al. 2022. Bioengineered. 13: 6978-6995. PMID: 35311623
- Calcitriol increases MBNL1 expression and alleviates myotonic dystrophy phenotypes in HSALR mouse models. | Huang, K., et al. 2022. J Transl Med. 20: 588. PMID: 36510245
- MBNL1-AS1 Promotes Hypoxia-Induced Myocardial Infarction via the miR-132-3p/RAB14/CAMTA1 Axis. | Li, Y., et al. 2023. Oxid Med Cell Longev. 2023: 3308725. PMID: 36785792
- Loss of MBNL1-mediated retrograde BDNF signaling in the myotonic dystrophy brain. | Wang, PY., et al. 2023. Acta Neuropathol Commun. 11: 44. PMID: 36922901
- MBNL1‑AS1 attenuates tumor cell proliferation by regulating the miR‑29c‑3p/BVES signal in colorectal cancer. | Chen, WS., et al. 2023. Oncol Rep. 50: PMID: 37711058
- Peptide-conjugated antimiRs improve myotonic dystrophy type 1 phenotypes by promoting endogenous MBNL1 expression. | González-Martínez, I., et al. 2023. Mol Ther Nucleic Acids. 34: 102024. PMID: 37744174
- FMRP deficiency leads to multifactorial dysregulation of splicing and mislocalization of MBNL1 to the cytoplasm. | Jung, S., et al. 2023. PLoS Biol. 21: e3002417. PMID: 38048343
- Studying the Effect of MBNL1 and MBNL2 Loss in Skeletal Muscle Regeneration. | Yadava, RS., et al. 2024. Int J Mol Sci. 25: PMID: 38473933
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MBNL1 Antibody (4A8) | sc-136165 | 200 µg/ml | $322.00 | |||
MBNL1 Antibody (4A8): m-IgG Fc BP-HRP Bundle | sc-539896 | 200 µg Ab; 10 µg BP | $361.00 | |||
MBNL1 Antibody (4A8): m-IgG1 BP-HRP Bundle | sc-541770 | 200 µg Ab; 20 µg BP | $361.00 |