MBD4 Antibody (A-8): sc-365974
- MBD4 Antibody (A-8) is a mouse monoclonal IgG2a κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 281-580 mapping near the C-terminus of MBD4 of human origin
- recommended for detection of MBD4 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MBD4 Antibody (A-8) for WB applications. These reagents are now offered in bundles with MBD4 Antibody (A-8) (see ordering information below).
QUICK LINKS
MBD4 Antibody (A-8) is a mouse monoclonal IgG2a antibody that detects MBD4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MBD4, also known as MED1, plays a crucial role in DNA damage repair by interacting with mismatch repair protein MLH1, which is essential for maintaining genomic stability. Anti-MBD4 antibody (A-8) preferentially binds to methylated cytosine residues in mismatched base pairs, thereby facilitating DNA repair and preventing mutations that could lead to various diseases, including cancer. MBD4′s presence in somatic tissues underscores its importance in cellular processes, particularly in epigenetic regulation and transcriptional repression associated with DNA methylation. Anti-MBD4 antibody (A-8) serves as an invaluable tool for researchers studying gene regulation and DNA repair pathways, providing insights into molecular underpinnings of genetic disorders and potential therapeutic targets.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MBD4 Antibody (A-8) References:
- The MBD4 gene plays an important role in porcine adipocyte differentiation. | Zhang, LJ., et al. 2014. Cell Physiol Biochem. 34: 1216-26. PMID: 25277759
- Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis. | Tricarico, R., et al. 2015. Oncotarget. 6: 42892-904. PMID: 26503472
- The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury. | Yu, AM., et al. 2016. Oncotarget. 7: 28624-36. PMID: 27086921
- Structural and mutation studies of two DNA demethylation related glycosylases: MBD4 and TDG. | Hashimoto, H. 2014. Biophysics (Nagoya-shi). 10: 63-8. PMID: 27493500
- MBD4 Facilitates Immunoglobulin Class Switch Recombination. | Grigera, F., et al. 2017. Mol Cell Biol. 37: PMID: 27777312
- Modification of the base excision repair enzyme MBD4 by the small ubiquitin-like molecule SUMO1. | Sannai, M., et al. 2019. DNA Repair (Amst). 82: 102687. PMID: 31476572
- Meta-analysis of the association between MBD4 Glu346Lys polymorphism and cancer risk. | Wang, J., et al. 2024. J Int Med Res. 52: 300060519895667. PMID: 31891275
- Germline MBD4 Mutations and Predisposition to Uveal Melanoma. | Derrien, AC., et al. 2021. J Natl Cancer Inst. 113: 80-87. PMID: 32239153
- MBD4 deficiency is predictive of response to immune checkpoint inhibitors in metastatic uveal melanoma patients. | Saint-Ghislain, M., et al. 2022. Eur J Cancer. 173: 105-112. PMID: 35863105
- A naturally occurring variant of MBD4 causes maternal germline hypermutation in primates. | Stendahl, AM., et al. 2023. Genome Res. 33: 2053-2059. PMID: 37984997
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MBD4 Antibody (A-8) | sc-365974 | 200 µg/ml | $322.00 | |||
MBD4 Antibody (A-8): m-IgGκ BP-HRP Bundle | sc-535290 | 200 µg Ab; 40 µg BP | $361.00 | |||
MBD4 Antibody (A-8): m-IgG2a BP-HRP Bundle | sc-546220 | 200 µg Ab; 10 µg BP | $361.00 |