MB67 Antibody (H-3): sc-518085
- MB67 Antibody (H-3) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1-26 at the N-terminus of MB67 of human origin
- MB67 Antibody (H-3) is recommended for detection of MB67 of human origin by WB, IP, IF and ELISA
- Anti-MB67 Antibody (H-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MB67 Antibody (H-3) for WB applications. These reagents are now offered in bundles with MB67 Antibody (H-3) (see ordering information below).
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MB67 Antibody (H-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects MB67 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MB67 antibody (H-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MB67, also known as constitutively acting receptor 1 (CAR1), plays a crucial role in regulating gene expression in the liver, where MB67 is predominantly expressed. MB67 belongs to a unique class of nuclear hormone receptors known as orphan receptors, characterized by their ability to activate transcription without a known ligand. Unlike traditional hormone receptors that require binding with specific hormones to initiate transcription, MB67 operates constitutively, forming heterodimers with retinoic-X receptors to bind DNA and activate target gene transcription. This unique mechanism allows for regulation of metabolic processes and detoxification pathways in the liver, highlighting MB67 ′s importance in maintaining cellular homeostasis and responding to physiological changes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MB67 Antibody (H-3) References:
- Role of Nuclear Constitutive Androstane Receptor in Regulation of Hepatocyte Proliferation and Hepatocarcinogenesis. | Kazantseva, YA., et al. 2016. Biochemistry (Mosc). 81: 338-47. PMID: 27293091
- Pregnane X receptor, constitutive androstane receptor and hepatocyte nuclear factors as emerging players in cancer precision medicine. | De Mattia, E., et al. 2016. Pharmacogenomics. 17: 1547-71. PMID: 27561454
- Constitutive androstane receptor and pregnane X receptor cooperatively ameliorate DSS-induced colitis. | Uehara, D., et al. 2019. Dig Liver Dis. 51: 226-235. PMID: 30442521
- Drug discovery technologies to identify and characterize modulators of the pregnane X receptor and the constitutive androstane receptor. | Chai, SC., et al. 2019. Drug Discov Today. 24: 906-915. PMID: 30731240
- Activation of the Constitutive Androstane Receptor Inhibits Leukocyte Adhesiveness to Dysfunctional Endothelium. | López-Riera, M., et al. 2021. Int J Mol Sci. 22: PMID: 34502180
- Constitutive androstane receptor and pregnane X receptor genotype influence efavirenz plasma concentration and CYP2B6 enzyme activity. | Petros, Z., et al. 2022. Sci Rep. 12: 9698. PMID: 35690682
- Constitutive androstane receptor (CAR) mediates pyrene-induced inflammatory responses in mouse liver, with increased serum amyloid A proteins and Th17 cells. | Shi, Z., et al. 2022. Br J Pharmacol. 179: 5209-5221. PMID: 35906855
- Constitutive androstane receptor-responsive elements for mouse Cyp1a2 transcriptional activation induced by constitutive androstane receptor ligands. | Kawasaki, Y., et al. 2023. Drug Metab Pharmacokinet. 48: 100485. PMID: 36740553
- Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor. | Cheng, X., et al. 2024. Mol Metab. 86: 101977. PMID: 38936659
- Constitutive Androstane Receptor Regulates Germ Cell Homeostasis, Sperm Quality, and Male Fertility via Akt-Foxo1 Pathway. | Monrose, M., et al. 2024. Adv Sci (Weinh). 11: e2402082. PMID: 39318179
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MB67 Antibody (H-3) | sc-518085 | 200 µg/ml | $316.00 | |||
MB67 Antibody (H-3): m-IgGκ BP-HRP Bundle | sc-525356 | 200 µg Ab, 40 µg BP | $354.00 | |||
MB67 Antibody (H-3): m-IgG2b BP-HRP Bundle | sc-549232 | 200 µg Ab; 10 µg BP | $354.00 | |||
MB67 Antibody (H-3) AC | sc-518085 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MB67 Antibody (H-3) HRP | sc-518085 HRP | 200 µg/ml | $316.00 | |||
MB67 Antibody (H-3) FITC | sc-518085 FITC | 200 µg/ml | $330.00 | |||
MB67 Antibody (H-3) PE | sc-518085 PE | 200 µg/ml | $343.00 | |||
MB67 Antibody (H-3) Alexa Fluor® 488 | sc-518085 AF488 | 200 µg/ml | $357.00 | |||
MB67 Antibody (H-3) Alexa Fluor® 546 | sc-518085 AF546 | 200 µg/ml | $357.00 | |||
MB67 Antibody (H-3) Alexa Fluor® 594 | sc-518085 AF594 | 200 µg/ml | $357.00 | |||
MB67 Antibody (H-3) Alexa Fluor® 647 | sc-518085 AF647 | 200 µg/ml | $357.00 | |||
MB67 Antibody (H-3) Alexa Fluor® 680 | sc-518085 AF680 | 200 µg/ml | $357.00 | |||
MB67 Antibody (H-3) Alexa Fluor® 790 | sc-518085 AF790 | 200 µg/ml | $357.00 |