MB67 Antibody (C-12): sc-518072
- MB67 Antibody (C-12) is a mouse monoclonal IgG3 MB67 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1-24 at the N-terminus of MB67 of human origin
- MB67 Antibody (C-12) is recommended for detection of MB67 of human origin by WB, IP, IF and ELISA
- Anti-MB67 Antibody (C-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MB67 Antibody (C-12). This work is in progress.
QUICK LINKS
SEE ALSO...
MB67 Antibody (C-12) is a mouse monoclonal IgG3 antibody that detects MB67 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MB67 antibody (C-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MB67 protein, also known as the Constitutive Androstane Receptor, plays a crucial role in regulating gene expression related to drug metabolism and detoxification processes, particularly in the liver, where MB67 is predominantly expressed. MB67 functions as a transcription factor that can activate gene transcription without ligand binding, distinguishing MB67 from conventional hormone receptors requiring ligand activation. MB67 forms heterodimers with the retinoic-X receptor to bind specific DNA sequences and regulate target genes involved in xenobiotic metabolism, making MB67 essential for maintaining cellular homeostasis and responding to environmental changes. Understanding MB67 function is vital for research into drug interactions and developing therapeutic strategies for liver-related diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MB67 Antibody (C-12) References:
- Constitutive androstane receptor (CAR) is a xenosensor and target for therapy. | Kachaylo, EM., et al. 2011. Biochemistry (Mosc). 76: 1087-97. PMID: 22098234
- The structure and function of steroid receptors. | Davies, P. and Rushmere, NK. 1988. Sci Prog. 72: 563-78. PMID: 3068798
- Constitutive androstane receptor (CAR) mediates dieldrin-induced liver tumorigenesis in mouse. | Wang, Z., et al. 2020. Arch Toxicol. 94: 2873-2884. PMID: 32435917
- Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR. | Küblbeck, J., et al. 2020. Cells. 9: PMID: 33076503
- Constitutive Androstane Receptor-Mediated Inhibition of Metformin on Phase II Metabolic Enzyme SULT2A1. | Hu, X., et al. 2021. Int J Endocrinol. 2021: 8867218. PMID: 33643408
- Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation. | Gao, Y., et al. 2021. Acta Pharm Sin B. 11: 727-737. PMID: 33777678
- Constitutive Androstane Receptor Agonist Initiates Metabolic Activity Required for Hepatocyte Proliferation. | Mazin, ME., et al. 2023. Biochemistry (Mosc). 88: 1061-1069. PMID: 37758307
- Pharmacological activation of constitutive androstane receptor induces female-specific modulation of hepatic metabolism. | Huillet, M., et al. 2024. JHEP Rep. 6: 100930. PMID: 38149074
- A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. | Baes, M., et al. 1994. Mol Cell Biol. 14: 1544-52. PMID: 8114692
- The RXR heterodimers and orphan receptors. | Mangelsdorf, DJ. and Evans, RM. 1995. Cell. 83: 841-50. PMID: 8521508
- Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR. | Choi, HS., et al. 1997. J Biol Chem. 272: 23565-71. PMID: 9295294
- Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. | Forman, BM., et al. 1998. Nature. 395: 612-5. PMID: 9783588
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MB67 Antibody (C-12) | sc-518072 | 200 µg/ml | $322.00 | |||
MB67 Antibody (C-12) AC | sc-518072 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MB67 Antibody (C-12) HRP | sc-518072 HRP | 200 µg/ml | $322.00 | |||
MB67 Antibody (C-12) FITC | sc-518072 FITC | 200 µg/ml | $336.00 | |||
MB67 Antibody (C-12) PE | sc-518072 PE | 200 µg/ml | $349.00 | |||
MB67 Antibody (C-12) Alexa Fluor® 488 | sc-518072 AF488 | 200 µg/ml | $364.00 | |||
MB67 Antibody (C-12) Alexa Fluor® 546 | sc-518072 AF546 | 200 µg/ml | $364.00 | |||
MB67 Antibody (C-12) Alexa Fluor® 594 | sc-518072 AF594 | 200 µg/ml | $364.00 | |||
MB67 Antibody (C-12) Alexa Fluor® 647 | sc-518072 AF647 | 200 µg/ml | $364.00 | |||
MB67 Antibody (C-12) Alexa Fluor® 680 | sc-518072 AF680 | 200 µg/ml | $364.00 | |||
MB67 Antibody (C-12) Alexa Fluor® 790 | sc-518072 AF790 | 200 µg/ml | $364.00 |