MATH-1 Antibody (18A6): sc-136173

MATH-1 Antibody (18A6) is a mouse monoclonal IgG1 kappa light chain antibody that detects MATH-1 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). MATH-1 (18A6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MATH-1 protein, also known as Atoh1, Ath1, or HATH-1, is a helix-loop-helix transcription factor consisting of 351 amino acids and is crucial for the development of the nervous system. MATH-1 (18A6) monoclonal antibody recognizes a protein structurally homologous to the Drosophila proneural gene atonal, which is essential for neural differentiation. MATH-1 is primarily expressed in the dorsal part of the central nervous system during embryonic development, with expression beginning around embryonic day 9.5. MATH-1 localization initially appears in cranial ganglions and later becomes restricted to the external granular layer of the cerebellum by day 18, ultimately becoming undetectable in the adult nervous system. This dynamic expression pattern suggests MATH-1 may play a pivotal role in the differentiation of specific neural cell subsets by activating E box-dependent transcription, highlighting MATH-1′s importance in neurogenesis and the proper formation of neural structures.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

MATH-1 Antibody (18A6) References:

1. Immature granule neurons from cerebella of different ages exhibit distinct developmental potentials.  |  Raetzman, LT. and Siegel, RE. 1999. J Neurobiol. 38: 559-70. PMID: 10084689
2. Expression of the basic Helix-Loop-Helix ME1 E-protein during development and aging of the murine cerebellum.  |  Uittenbogaard, M. and Chiaramello, A. 1999. Neurosci Lett. 274: 191-4. PMID: 10548422
3. Zic1 represses Math1 expression via interactions with the Math1 enhancer and modulation of Math1 autoregulation.  |  Ebert, PJ., et al. 2003. Development. 130: 1949-59. PMID: 12642498
4. Molecular mechanisms for morphogenesis of the central nervous system in mammals.  |  Ishibashi, M. 2004. Anat Sci Int. 79: 226-34. PMID: 15633461
5. Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cells.  |  Liu, T., et al. 2007. Carcinogenesis. 28: 488-96. PMID: 16990345
6. MATH-1 production by an adult medulloblastoma suggestive of a cerebellar external granule cell precursor origin.  |  Ueba, T., et al. 2008. J Clin Neurosci. 15: 84-7. PMID: 18032051
7. Cell proliferation during hair cell regeneration induced by Math1 in vestibular epithelia in vitro.  |  Huang, YB., et al. 2018. Neural Regen Res. 13: 497-501. PMID: 29623936
8. IL-22 promotes mucin-type O-glycosylation and MATH1+ cell-mediated amelioration of intestinal inflammation.  |  Singh, A., et al. 2024. Cell Rep. 43: 114206. PMID: 38733584
9. A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system.  |  Akazawa, C., et al. 1995. J Biol Chem. 270: 8730-8. PMID: 7721778
10. Genetic mapping of four mouse bHLH genes related to Drosophila proneural gene atonal.  |  Isaka, F., et al. 1996. Genomics. 37: 400-2. PMID: 8938455
11. XATH-1, a vertebrate homolog of Drosophila atonal, induces a neuronal differentiation within ectodermal progenitors.  |  Kim, P., et al. 1997. Dev Biol. 187: 1-12. PMID: 9224669
12. Gene expression of MASH-1, MATH-1, neuroD and NSCL-2, basic helix-loop-helix proteins, during neural differentiation in P19 embryonal carcinoma cells.  |  Itoh, F., et al. 1997. Tohoku J Exp Med. 182: 327-36. PMID: 9352625

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MATH-1 Antibody (18A6) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-MATH-1 Antibody (18A6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MATH-1 Antibody (18A6) Specifications

Alternate Product Name: MATH-1

Product Clone Name: 18A6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2-189

Epitope Target: MATH-1

Epitope Species: human

Product Reactivity/Detection: MATH-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for MATH-1 Antibody (18A6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin