Maspin Antibody (E-10): sc-166260
- Maspin Antibody (E-10) is a mouse monoclonal IgG2a κ, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 51-180 mapping near the N-terminus of Maspin of human origin
- recommended for detection of Maspin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Maspin Antibody (E-10) for WB and IHC(P) applications. These reagents are now offered in bundles with Maspin Antibody (E-10) (see ordering information below).
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Maspin Antibody (E-10) is a mouse monoclonal IgG2a antibody that detects maspin in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Maspin is a member of the serpin family, functioning primarily as a serine protease inhibitor, and plays a crucial role in regulating cell motility and invasion, particularly in cancer. Maspin′s presence in the extracellular matrix and at the plasma membrane is vital, as anti-maspin antibody (E-10) helps reveal how maspin inhibits invasive properties of breast and prostate cancer cells, contributing to tumor suppression. Maspin expression typically occurs in normal mammary and prostate epithelial cells but is often down-regulated or absent in various tumor cell lines, indicating potential as a biomarker for cancer progression. Despite expression loss in tumor cells, no significant structural alterations in maspin genes have been identified, suggesting epigenetic factors may influence regulation. Maspin (E-10) antibody serves as an essential tool for researchers investigating cancer invasion and metastasis mechanisms, providing insights into therapeutic potential in cancer treatment.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
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Maspin Antibody (E-10) References:
- Maspin--a novel protease inhibitor with tumor-suppressing activity in breast cancer. | Maass, N., et al. 2000. Acta Oncol. 39: 931-4. PMID: 11206999
- Tumor suppressive maspin and epithelial homeostasis. | Lockett, J., et al. 2006. J Cell Biochem. 97: 651-60. PMID: 16329135
- MASPIN tumour-suppressing activity in head and neck squamous cell carcinoma: emerging evidence and therapeutic perspectives. | Marioni, G., et al. 2009. Acta Otolaryngol. 129: 476-80. PMID: 18615330
- Maspin-related Orchestration of Aggressiveness of Gastric Cancer. | Gurzu, S., et al. 2016. Appl Immunohistochem Mol Morphol. 24: 326-36. PMID: 26067133
- Tumor suppressor maspin as a modulator of host immune response to cancer. | Dzinic, SH., et al. 2015. Bosn J Basic Med Sci. 15: 1-6. PMID: 26614844
- The roles of MASPIN expression and subcellular localization in non-small cell lung cancer. | Wang, XF., et al. 2020. Biosci Rep. 40: PMID: 32391558
- Hypoxia-induced Maspin Expression Affects the Prognosis of Ovarian Clear Cell Carcinoma. | Lee, EJ., et al. 2022. In Vivo. 36: 212-220. PMID: 34972717
- Integrating the tumor-suppressive activity of Maspin with p53 in retuning the epithelial homeostasis: A working hypothesis and applicable prospects. | Tang, S., et al. 2022. Front Oncol. 12: 1037794. PMID: 36523976
- P176S Mutation Rewires Electrostatic Interactions That Alter Maspin Functionality. | Anwar, MA., et al. 2023. ACS Omega. 8: 28258-28267. PMID: 37576651
- HDAC5-mediated exosomal Maspin and miR-151a-3p as biomarkers for enhancing radiation treatment sensitivity in hepatocellular carcinoma. | Lee, SM., et al. 2023. Biomater Res. 27: 134. PMID: 38102691
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Maspin Antibody (E-10) | sc-166260 | 200 µg/ml | $322.00 | |||
Maspin Antibody (E-10): m-IgG Fc BP-HRP Bundle | sc-537466 | 200 µg Ab; 10 µg BP | $361.00 | |||
Maspin Antibody (E-10): m-IgGκ BP-HRP Bundle | sc-534742 | 200 µg Ab; 40 µg BP | $361.00 | |||
Maspin Antibody (E-10): m-IgG2a BP-HRP Bundle | sc-548023 | 200 µg Ab; 10 µg BP | $361.00 |