MASP-1/3 Antibody (G-7): sc-166816

MASP-1/3 Antibody (G-7) is a mouse monoclonal IgG2b antibody that detects MASP-1/3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MASP-1/3, or MBL-associated serine protease 1 and 3, plays a crucial role in the lectin pathway of the complement system, which is essential for the innate immune response. These serine proteases are activated upon binding of mannose-binding lectin to pathogens, leading to the cleavage and activation of downstream complement components that help neutralize invading microorganisms. MASP-1/3′s importance lies in bridging the innate and adaptive immune responses, enhancing the body′s defense mechanisms against infections. Notably, MASP-3 is an alternatively spliced product of the MASP-1 gene, sharing identical heavy chains but differing in their light chains, which highlights the complexity and regulatory mechanisms of the complement system. MASP-1/3 (G-7) antibody serves as an invaluable tool for researchers studying immune responses, complement activation, and the pathophysiology of immunodeficiencies associated with mutations in the MBL pathway.

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MASP-1/3 Antibody (G-7) References:

1. Functional characterization of human mannose-binding lectin-associated serine protease (MASP)-1/3 and MASP-2 promoters, and comparison with the C1s promoter.  |  Endo, Y., et al. 2002. Int Immunol. 14: 1193-201. PMID: 12356684
2. Origin of mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 involved in the lectin complement pathway traced back to the invertebrate, amphioxus.  |  Endo, Y., et al. 2003. J Immunol. 170: 4701-7. PMID: 12707349
3. Murine serine proteases MASP-1 and MASP-3, components of the lectin pathway activation complex of complement, are encoded by a single structural gene.  |  Stover, CM., et al. 2003. Genes Immun. 4: 374-84. PMID: 12847554
4. Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity.  |  Hansen, S., et al. 2010. J Immunol. 185: 6096-104. PMID: 20956340
5. Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function.  |  Degn, SE., et al. 2012. J Immunol. 189: 3957-69. PMID: 22966085
6. C3 dysregulation due to factor H deficiency is mannan-binding lectin-associated serine proteases (MASP)-1 and MASP-3 independent in vivo.  |  Ruseva, MM., et al. 2014. Clin Exp Immunol. 176: 84-92. PMID: 24279761
7. Plasma levels of MASP-1, MASP-3 and MAp44 in patients with type 2 diabetes: influence of glycaemic control, body composition and polymorphisms in the MASP1 gene.  |  Krogh, SS., et al. 2017. Clin Exp Immunol. 189: 103-112. PMID: 28318015
8. MASP-1 and MASP-2 Serum Levels Are Associated With Worse Prognostic in Cervical Cancer Progression.  |  Maestri, CA., et al. 2018. Front Immunol. 9: 2742. PMID: 30532757
9. Systematic analysis of MASP-1 serves as a novel immune-related biomarker in sepsis and trauma followed by preliminary experimental validation.  |  Xian, L., et al. 2024. Front Med (Lausanne). 11: 1320811. PMID: 38384415
10. Complement MASP-1 Modifies Endothelial Wound Healing.  |  Németh, Z., et al. 2024. Int J Mol Sci. 25: PMID: 38612857

The preferred MASP-1/3 antibody is MASP-1/3 Antibody (F-12): sc-166815.