MAGE-C1 Antibody (CT7-33): sc-53868
- MAGE-C1 Antibody (CT7-33) is a mouse monoclonal IgG1 κ MAGE-C1 antibody, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 552-901 of MAGE-C1 of human origin
- MAGE-C1 Antibody (CT7-33) is recommended for detection of MAGE-C1 of human origin by WB, IP, IF and IHC(P)
- Anti-MAGE-C1 Antibody (CT7-33) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MAGE-C1 Antibody (CT7-33) for WB and IHC(P) applications. These reagents are now offered in bundles with MAGE-C1 Antibody (CT7-33) (see ordering information below).
MAGE-C1 Antibody (CT7-33) is a mouse monoclonal IgG1 kappa light chain antibody that detects MAGE-C1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. MAGE-C1 (CT7-33) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The melanoma-associated antigen (MAGE) family, to which MAGE-C1 belongs, is known for its role in eliciting immune responses against tumors, as these antigens are recognized by cytotoxic T lymphocytes. MAGE-C1, also referred to as CT7, is particularly significant due to expression in multiple myeloma, where MAGE-C1 correlates with plasma-cell proliferation, highlighting potential as a biomarker for this malignancy. MAGE-C1 is primarily located in the cytoplasm and nucleus of tumor cells, which is crucial for function in tumor rejection and immune evasion. Understanding MAGE-C1 cellular localization is important, as this knowledge may influence the development of targeted therapies aimed at enhancing immune recognition of cancer cells. Notably, MAGE-C1 is expressed in various tumors but remains absent in normal tissues, except for the testis and placenta, making MAGE-C1 a promising target for cancer immunotherapy.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MAGE-C1 Antibody (CT7-33) References:
- Mage-b4, a novel melanoma antigen (MAGE) gene specifically expressed during germ cell differentiation. | Osterlund, C., et al. 2000. Cancer Res. 60: 1054-61. PMID: 10706124
- A MAGE-A1 peptide is recognized on HLA-B7 human tumors by cytolytic T lymphocytes. | Luiten, R. and van der Bruggen, P. 2000. Tissue Antigens. 55: 149-52. PMID: 10746786
- Expression of MAGE, GAGE and BAGE genes in human liver diseases: utility as molecular markers for hepatocellular carcinoma. | Kobayashi, Y., et al. 2000. J Hepatol. 32: 612-7. PMID: 10782910
- Immunoreactivity with the anti-MAGE antibody 57B in malignant melanoma: frequency of expression and correlation with prognostic parameters. | Busam, KJ., et al. 2000. Mod Pathol. 13: 459-65. PMID: 10786815
- Comparative analysis of genetically modified dendritic cells and tumor cells as therapeutic cancer vaccines. | Klein, C., et al. 2000. J Exp Med. 191: 1699-708. PMID: 10811863
- Melanoma antigen genes 1 and 2 are differentially expressed in human gastric and cardial carcinomas. | Granelli, P., et al. 2000. Scand J Gastroenterol. 35: 528-33. PMID: 10868457
- Genetic detection for micrometastasis in lymph node of biliary tract carcinoma. | Okami, J., et al. 2000. Clin Cancer Res. 6: 2326-32. PMID: 10873083
- CT7 (MAGE-C1) antigen expression in normal and neoplastic tissues. | Jungbluth, AA., et al. 2002. Int J Cancer. 99: 839-45. PMID: 12115486
- The cancer-testis antigens CT7 (MAGE-C1) and MAGE-A3/6 are commonly expressed in multiple myeloma and correlate with plasma-cell proliferation. | Jungbluth, AA., et al. 2005. Blood. 106: 167-74. PMID: 15761016
- Expression of MAGE-C1/CT7 and MAGE-C2/CT10 predicts lymph node metastasis in melanoma patients. | Curioni-Fontecedro, A., et al. 2011. PLoS One. 6: e21418. PMID: 21738656
- The expression of MAGE-C1 and MAGE-C2 in breast cancer and their clinical significance. | Hou, S., et al. 2016. Am J Surg. 211: 142-51. PMID: 26321295
- High expression of MAGE-C1 gene in colorectal cancer is associated with its poor prognosis. | Tian, Y., et al. 2021. J Gastrointest Oncol. 12: 2872-2881. PMID: 35070414
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MAGE-C1 Antibody (CT7-33) | sc-53868 | 200 µg/ml | $316.00 | |||
MAGE-C1 Antibody (CT7-33): m-IgG Fc BP-HRP Bundle | sc-528581 | 200 µg Ab; 10 µg BP | $354.00 | |||
MAGE-C1 Antibody (CT7-33): m-IgGκ BP-HRP Bundle | sc-520992 | 200 µg Ab, 40 µg BP | $354.00 | |||
MAGE-C1 Antibody (CT7-33) AC | sc-53868 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MAGE-C1 Antibody (CT7-33) HRP | sc-53868 HRP | 200 µg/ml | $316.00 | |||
MAGE-C1 Antibody (CT7-33) FITC | sc-53868 FITC | 200 µg/ml | $330.00 | |||
MAGE-C1 Antibody (CT7-33) PE | sc-53868 PE | 200 µg/ml | $343.00 | |||
MAGE-C1 Antibody (CT7-33) Alexa Fluor® 488 | sc-53868 AF488 | 200 µg/ml | $357.00 | |||
MAGE-C1 Antibody (CT7-33) Alexa Fluor® 546 | sc-53868 AF546 | 200 µg/ml | $357.00 | |||
MAGE-C1 Antibody (CT7-33) Alexa Fluor® 594 | sc-53868 AF594 | 200 µg/ml | $357.00 | |||
MAGE-C1 Antibody (CT7-33) Alexa Fluor® 647 | sc-53868 AF647 | 200 µg/ml | $357.00 | |||
MAGE-C1 Antibody (CT7-33) Alexa Fluor® 680 | sc-53868 AF680 | 200 µg/ml | $357.00 | |||
MAGE-C1 Antibody (CT7-33) Alexa Fluor® 790 | sc-53868 AF790 | 200 µg/ml | $357.00 |