MafB Antibody (B-11): sc-376387
- MafB Antibody (B-11) is a mouse monoclonal IgG2b κ, cited in 7 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1-25 near the N-terminus of MafB of human origin
- recommended for detection of MafB of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-376387 X, 200 µg/0.1 ml)
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MafB Antibody (B-11) for WB applications. These reagents are now offered in bundles with MafB Antibody (B-11) (see ordering information below).
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MafB Antibody (B-11) is a mouse monoclonal IgG2b antibody that detects MafB in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MafB is a crucial transcription factor that plays a significant role in hematopoiesis, particularly in regulating lineage-specific gene expression. MafB contains a basic region/leucine zipper (bZIP) motif in its carboxy-terminal region, which is essential for function as a transcriptional activator. By repressing Ets-1-mediated transcription of key erythroid-specific genes in myeloid cells, MafB ensures proper differentiation and development of blood cells. This regulatory mechanism is vital for maintaining the balance of cell types in the hematopoietic system, highlighting MafB′s importance in both normal physiology and potential pathological conditions. Anti-MafB antibody (B-11) serves as an invaluable tool for researchers studying the intricate processes of blood cell development and the underlying mechanisms of related disorders.
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MafB Antibody (B-11) References:
- Identification of primary MAFB target genes in multiple myeloma. | van Stralen, E., et al. 2009. Exp Hematol. 37: 78-86. PMID: 19013005
- Cdx1 refines positional identity of the vertebrate hindbrain by directly repressing Mafb expression. | Sturgeon, K., et al. 2011. Development. 138: 65-74. PMID: 21098558
- MafB is a critical regulator of complement component C1q. | Tran, MTN., et al. 2017. Nat Commun. 8: 1700. PMID: 29167450
- Transcription factor MafB is a marker of tumor-associated macrophages in both mouse and humans. | Yadav, MK., et al. 2020. Biochem Biophys Res Commun. 521: 590-595. PMID: 31679694
- Periodontitis Risk Variants at SIGLEC5 Impair ERG and MAFB Binding. | Mueller, R., et al. 2022. J Dent Res. 101: 551-558. PMID: 34852650
- Activation of RARα Receptor Attenuates Neuroinflammation After SAH via Promoting M1-to-M2 Phenotypic Polarization of Microglia and Regulating Mafb/Msr1/PI3K-Akt/NF-κB Pathway. | Tian, Y., et al. 2022. Front Immunol. 13: 839796. PMID: 35237277
- Transcription Factor MAFB as a Prognostic Biomarker for the Lung Adenocarcinoma. | Samir, O., et al. 2022. Int J Mol Sci. 23: PMID: 36077342
- MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation. | Vanneste, D., et al. 2023. Nat Immunol. 24: 827-840. PMID: 36928411
- Multicentric carpotarsal osteolysis syndrome with variants of MAFB gene: a case report and literature review. | Gao, X., et al. 2024. Pediatr Rheumatol Online J. 22: 37. PMID: 38481224
- MAFB in macrophages regulates cold-induced neuronal density in brown adipose tissue. | Yadav, MK., et al. 2024. Cell Rep. 43: 113978. PMID: 38522069
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MafB Antibody (B-11) | sc-376387 | 200 µg/ml | $316.00 | |||
MafB Antibody (B-11): m-IgGκ BP-HRP Bundle | sc-535484 | 200 µg Ab; 40 µg BP | $354.00 | |||
MafB Antibody (B-11): m-IgG2b BP-HRP Bundle | sc-549429 | 200 µg Ab; 10 µg BP | $354.00 | |||
MafB (B-11) Neutralizing Peptide | sc-376387 P | 100 µg/0.5 ml | $68.00 | |||
MafB Antibody (B-11) X | sc-376387 X | 200 µg/0.1 ml | $316.00 |