MAdCAM-1 Antibody (F-6): sc-374398

MAdCAM-1 Antibody (F-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects MAdCAM-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MAdCAM-1 antibody (F-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MAdCAM-1, or mucosal addressin cell adhesion molecule 1, is a crucial immunoglobulin superfamily adhesion molecule that facilitates lymphocyte homing to mucosal tissues. MAdCAM-1 expression occurs primarily on mucosal venule endothelium, where interactions with leukocyte homing receptors like L-Selectin and Integrin α4/β7 guide lymphocytes into Peyer′s patches and intestinal lamina propria. Such targeted trafficking maintains mucosal immunity and ensures effective immune responses in the gut. MAdCAM-1 upregulation occurs in inflammatory conditions, particularly autoimmune diseases, contributing to immune cell recruitment at inflammation sites, as seen in chronic experimental autoimmune encephalomyelitis and autoimmune-mediated liver disease. MAdCAM-1′s role in mediating these interactions highlights its significance in normal immune function and pathological conditions, making MAdCAM-1 (F-6) monoclonal antibody valuable for studying immune responses and related diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MAdCAM-1 Antibody (F-6) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-MAdCAM-1 Antibody (F-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MAdCAM-1 Antibody (F-6) Specifications

Alternate Product Name: MAdCAM-1

Product Clone Name: F-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 5-43

Epitope Target: MAdCAM-1

Epitope Species: mouse

Product Reactivity/Detection: MAdCAM-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for MAdCAM-1 Antibody (F-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred MAdCAM-1 antibody is MAdCAM-1 Antibody (H-3): sc-365934.