Ly-49F Antibody (HBF-719): sc-53023

Ly-49F Antibody (HBF-719) is a mouse monoclonal IgG1 antibody that detects Ly-49F in mouse samples through flow cytometry (FCM). Ly-49F is a member of the Ly-49 family of receptors, which are critical for the regulation of natural killer (NK) cell activity. These receptors play a vital role in the immune response by recognizing and binding to specific ligands on target cells, thereby influencing NK cell activation and inhibition. The structure of Ly-49F contains a C-type lectin-like domain that facilitates interaction with MHC class I molecules, allowing NK cells to distinguish between healthy and stressed or infected cells. This ability to recognize altered self-cells is crucial for maintaining immune surveillance and preventing tumor proliferation. Ly-49F is predominantly expressed on NK cell surfaces, where Ly-49F contributes to the fine-tuning of immune responses, making Ly-49F an essential target for studies focused on cancer immunology and therapeutic interventions. Anti-Ly-49F antibody (HBF-719) serves as an invaluable tool for researchers investigating NK cell function dynamics and immune regulation roles.

The preferred Ly-49 antibody is Ly-49 Antibody (14B11): sc-53022.