Ly-49 Antibody (14B11): sc-53022

Ly-49 Antibody (14B11) is a hamster monoclonal IgG antibody that detects the Ly-49 protein of mouse origin by flow cytometry (FCM). Anti-Ly-49 antibody (14B11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. Ly-49 protein plays a crucial role in the regulation of natural killer (NK) cell activity, which is essential for the immune response against tumors and virally infected cells. Specifically, Ly-49 proteins are part of the C-type lectin superfamily and function as receptors that recognize class I major histocompatibility complex (MHC) molecules, allowing NK cells to distinguish between healthy and abnormal cells. Ly-49′s ability to form homodimers enhances its capacity to mediate inhibitory signals, thereby preventing the activation of NK cells against normal cells while allowing for the targeting of stressed or transformed cells. With at least 21 known isoforms, each varying in length from 230 to 280 amino acids, the diversity of Ly-49 proteins contributes to the complexity of immune regulation, making anti-Ly-49 antibody (14B11) an invaluable tool for researchers studying NK cell biology and immune responses in mouse models.

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Ly-49 Antibody (14B11) References:

1. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.  |  Bauer, S., et al. 1999. Science. 285: 727-9. PMID: 10426993
2. Inhibitory role of murine Ly49 lectin-like receptors on natural killer cells.  |  Salcedo, M. 1999. Curr Top Microbiol Immunol. 244: 97-105. PMID: 10453652
3. Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors.  |  Hayami, K., et al. 1997. J Biol Chem. 272: 7320-7. PMID: 9054430
4. The Ly-49 family: genes, proteins and recognition of class I MHC.  |  Takei, F., et al. 1997. Immunol Rev. 155: 67-77. PMID: 9059883
5. Divergent functions of lectin-like receptors on NK cells.  |  Ryan, JC. and Seaman, WE. 1997. Immunol Rev. 155: 79-89. PMID: 9059884
6. Natural killer cell receptors.  |  Long, EO. and Wagtmann, N. 1997. Curr Opin Immunol. 9: 344-50. PMID: 9203417
7. HLA class I specific inhibitory receptors.  |  Moretta, A. and Moretta, L. 1997. Curr Opin Immunol. 9: 694-701. PMID: 9368779
8. Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells.  |  Vance, RE., et al. 1997. Eur J Immunol. 27: 3236-41. PMID: 9464811
9. The major SHP-1-binding, tyrosine-phosphorylated protein in macrophages is a member of the KIR/LIR family and an SHP-1 substrate.  |  Berg, KL., et al. 1998. Oncogene. 17: 2535-41. PMID: 9824165

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ly-49 Antibody (14B11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Ly-49 Antibody (14B11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ly-49 Antibody (14B11) Specifications

Alternate Product Name: Ly-49

Product Clone Name: 14B11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG

Amino Acids:

Epitope Target: Ly-49

Epitope Species: mouse

Product Reactivity/Detection: Ly-49C, Ly-49F, Ly-49H and Ly-49I

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: FCM

Vialing Information: Each vial contains 200 µg IgG in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Ly-49 Antibody (14B11): FITC: Fluoroscein, PE: Phycoerythrin