LXR alpha/beta/NR1H3/NR1H2 Antibody (H-7): sc-377260

LXRα/β Antibody (H-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects LXRα/β protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LXRα/β Antibody (H-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LXRα and LXRβ proteins are crucial for regulating lipid metabolism and play a significant role in maintaining cellular cholesterol homeostasis. These proteins function as transcription factors that, upon binding to their ligands, activate the expression of genes involved in lipid transport and metabolism, thereby influencing processes such as cholesterol efflux and fatty acid synthesis. This regulation is particularly important in the liver and macrophages, where dysregulation can lead to metabolic disorders such as atherosclerosis and fatty liver disease. The interaction of LXR with retinoid X receptor (RXR) further enhances its ability to modulate gene expression, highlighting the intricate network of nuclear receptors involved in lipid homeostasis. LXRα and LXRβ share a high degree of sequence homology and are responsive to both endogenous and synthetic ligands, making these proteins vital targets for therapeutic interventions aimed at metabolic diseases.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LXR alpha/beta/NR1H3/NR1H2 Antibody (H-7) has 22 citations in a variety of scientific publications.

Primary antibodies like Anti-LXR alpha/beta/NR1H3/NR1H2 Antibody (H-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LXR alpha/beta/NR1H3/NR1H2 Antibody (H-7) Specifications

Alternate Product Name: LXRα/β

Product Clone Name: H-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 433-461

Epitope Target: LXRβ

Epitope Species: human

Product Reactivity/Detection: LXRα and LXRβ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 22 citations in various scientific publications

Available Conjugates/Forms for LXR alpha/beta/NR1H3/NR1H2 Antibody (H-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin, X: TransCruz Reagent

The preferred LXR alpha/beta/NR1H3/NR1H2 antibody is LXR alpha/beta/NR1H3/NR1H2 Antibody (G-10): sc-271064.