LTBP-3 Antibody (H-11): sc-390913
- LTBP-3 Antibody (H-11) is a mouse monoclonal IgG1 κ LTBP-3 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1041-1250 deletion 1082-1129; deletion 1082-1129 mapping near the C-terminus of LTBP-3 of human origin
- LTBP-3 Antibody (H-11) is recommended for detection of LTBP-3 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-LTBP-3 Antibody (H-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LTBP-3 Antibody (H-11) for WB applications. These reagents are now offered in bundles with LTBP-3 Antibody (H-11) (see ordering information below).
LTBP-3 Antibody (H-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects LTBP-3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LTBP-3 Antibody (H-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LTBP-3, or latent TGF-beta-binding protein 3, serves as a crucial structural component of connective tissue microfibrils, significantly influencing the secretion and targeting of TGF-beta1, a key regulator in cellular processes such as proliferation, differentiation, and immune response. Proper functioning of LTBP-3 is vital for maintaining extracellular matrix integrity and facilitating tissue repair, making LTBP-3 an important protein in both normal physiology and pathological conditions. High expression levels of LTBP-3 have been observed in human heart, skeletal muscle, prostate, and ovaries, as well as in certain osteosarcoma and fibroblastic cell lines, indicating LTBP-3′s relevance in various biological contexts. Additionally, human LTBP-3 is located on chromosome 11q12, further emphasizing LTBP-3′s significance in genetic studies and potential therapeutic targets.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LTBP-3 Antibody (H-11) References:
- Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion. | Chen, Y., et al. 2002. FEBS Lett. 517: 277-80. PMID: 12062452
- Secretion of human latent TGF-beta-binding protein-3 (LTBP-3) is dependent on co-expression of TGF-beta. | Penttinen, C., et al. 2002. J Cell Sci. 115: 3457-68. PMID: 12154076
- Bone defects in latent TGF-beta binding protein (Ltbp)-3 null mice; a role for Ltbp in TGF-beta presentation. | Dabovic, B., et al. 2002. J Endocrinol. 175: 129-41. PMID: 12379497
- Growth retardation as well as spleen and thymus involution in latent TGF-beta binding protein (Ltbp)-3 null mice. | Chen, Y., et al. 2003. J Cell Physiol. 196: 319-25. PMID: 12811825
- Lung alveolar septation defects in Ltbp-3-null mice. | Colarossi, C., et al. 2005. Am J Pathol. 167: 419-28. PMID: 16049328
- Induction of human LTBP-3 promoter activity by TGF-beta1 is mediated by Smad3/4 and AP-1 binding elements. | Kantola, AK., et al. 2005. Gene. 363: 142-50. PMID: 16223572
- Isolation of a novel latent transforming growth factor-beta binding protein gene (LTBP-3). | Yin, W., et al. 1995. J Biol Chem. 270: 10147-60. PMID: 7730318
- Alternative splicing of LTBP-3. | Yin, W., et al. 1998. Biochem Biophys Res Commun. 245: 454-8. PMID: 9571174
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LTBP-3 Antibody (H-11) | sc-390913 | 200 µg/ml | $322.00 | |||
LTBP-3 Antibody (H-11): m-IgG Fc BP-HRP Bundle | sc-530300 | 200 µg Ab; 10 µg BP | $361.00 | |||
LTBP-3 Antibody (H-11): m-IgGκ BP-HRP Bundle | sc-523731 | 200 µg Ab, 40 µg BP | $361.00 | |||
LTBP-3 Antibody (H-11): m-IgG1 BP-HRP Bundle | sc-543981 | 200 µg Ab; 20 µg BP | $361.00 | |||
LTBP-3 Antibody (H-11) AC | sc-390913 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LTBP-3 Antibody (H-11) HRP | sc-390913 HRP | 200 µg/ml | $322.00 | |||
LTBP-3 Antibody (H-11) FITC | sc-390913 FITC | 200 µg/ml | $336.00 | |||
LTBP-3 Antibody (H-11) PE | sc-390913 PE | 200 µg/ml | $349.00 | |||
LTBP-3 Antibody (H-11) Alexa Fluor® 488 | sc-390913 AF488 | 200 µg/ml | $364.00 | |||
LTBP-3 Antibody (H-11) Alexa Fluor® 546 | sc-390913 AF546 | 200 µg/ml | $364.00 | |||
LTBP-3 Antibody (H-11) Alexa Fluor® 594 | sc-390913 AF594 | 200 µg/ml | $364.00 | |||
LTBP-3 Antibody (H-11) Alexa Fluor® 647 | sc-390913 AF647 | 200 µg/ml | $364.00 | |||
LTBP-3 Antibody (H-11) Alexa Fluor® 680 | sc-390913 AF680 | 200 µg/ml | $364.00 | |||
LTBP-3 Antibody (H-11) Alexa Fluor® 790 | sc-390913 AF790 | 200 µg/ml | $364.00 |