LTBP-2 Antibody (E-10): sc-166199
- LTBP-2 Antibody (E-10) is a mouse monoclonal IgG2b κ LTBP-2 antibody, cited in 7 publications, provided at 200 µg/ml
- raised against amino acids 211-480 mapping within an internal region of LTBP-2 of human origin
- LTBP-2 Antibody (E-10) is recommended for detection of LTBP-2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-LTBP-2 Antibody (E-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LTBP-2 Antibody (E-10) for WB applications. These reagents are now offered in bundles with LTBP-2 Antibody (E-10) (see ordering information below).
LTBP-2 Antibody (E-10) is a mouse monoclonal IgG2b kappa light chain antibody that detects LTBP-2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LTBP-2 (E-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LTBP-2 plays a crucial role in regulating transforming growth factor beta (TGF-β) signaling, as part of a latent complex secreted alongside TGF-β. LTBP-2 is essential for proper assembly and stabilization of the extracellular matrix, particularly in tissues rich in elastin, such as lung and heart. LTBP-2 features a multidomain structure, including 20 epidermal growth factor-like repeats and four 8-cysteine motifs, contributing to interactions with other extracellular matrix components. LTBP-2 localization within elastin-containing microfibrils maintains tissue elasticity and integrity, and LTBP-2 dysregulation has been implicated in conditions such as pseudoexfoliation syndrome, where abnormal fibrillar material accumulates in various tissues. LTBP-2 gene is located on human chromosome 14q24, highlighting significance in genetic studies related to connective tissue disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LTBP-2 Antibody (E-10) References:
- Developmental expression of latent transforming growth factor beta binding protein 2 and its requirement early in mouse development. | Shipley, JM., et al. 2000. Mol Cell Biol. 20: 4879-87. PMID: 10848613
- Role of transforming growth factor-beta1 and its latent form binding protein in pseudoexfoliation syndrome. | Schlötzer-Schrehardt, U., et al. 2001. Exp Eye Res. 73: 765-80. PMID: 11846508
- Expression of latent TGF-beta binding proteins and association with TGF-beta 1 and fibrillin-1 following arterial injury. | Sinha, S., et al. 2002. Cardiovasc Res. 53: 971-83. PMID: 11922907
- Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein. | Morén, A., et al. 1994. J Biol Chem. 269: 32469-78. PMID: 7798248
- Analysis of the human gene encoding latent transforming growth factor-beta-binding protein-2. | Bashir, MM., et al. 1996. Int J Biochem Cell Biol. 28: 531-42. PMID: 8697098
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LTBP-2 Antibody (E-10) | sc-166199 | 200 µg/ml | $322.00 | |||
LTBP-2 Antibody (E-10): m-IgG Fc BP-HRP Bundle | sc-528919 | 200 µg Ab; 10 µg BP | $361.00 | |||
LTBP-2 Antibody (E-10): m-IgGκ BP-HRP Bundle | sc-521531 | 200 µg Ab, 40 µg BP | $361.00 | |||
LTBP-2 Antibody (E-10) AC | sc-166199 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LTBP-2 Antibody (E-10) HRP | sc-166199 HRP | 200 µg/ml | $322.00 | |||
LTBP-2 Antibody (E-10) FITC | sc-166199 FITC | 200 µg/ml | $336.00 | |||
LTBP-2 Antibody (E-10) PE | sc-166199 PE | 200 µg/ml | $349.00 | |||
LTBP-2 Antibody (E-10) Alexa Fluor® 488 | sc-166199 AF488 | 200 µg/ml | $364.00 | |||
LTBP-2 Antibody (E-10) Alexa Fluor® 546 | sc-166199 AF546 | 200 µg/ml | $364.00 | |||
LTBP-2 Antibody (E-10) Alexa Fluor® 594 | sc-166199 AF594 | 200 µg/ml | $364.00 | |||
LTBP-2 Antibody (E-10) Alexa Fluor® 647 | sc-166199 AF647 | 200 µg/ml | $364.00 | |||
LTBP-2 Antibody (E-10) Alexa Fluor® 680 | sc-166199 AF680 | 200 µg/ml | $364.00 | |||
LTBP-2 Antibody (E-10) Alexa Fluor® 790 | sc-166199 AF790 | 200 µg/ml | $364.00 |