LSP1 Antibody (TDP153): sc-53363
- LSP1 Antibody (TDP153) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against tonsil cells of human origin
- LSP1 Antibody (TDP153) is recommended for detection of LSP1 of human origin by WB, IP, IF and IHC(P)
- Anti-LSP1 Antibody (TDP153) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LSP1 Antibody (TDP153) for WB and IHC(P) applications. These reagents are now offered in bundles with LSP1 Antibody (TDP153) (see ordering information below).
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SEE ALSO...
LSP1 Antibody (TDP153) is a mouse monoclonal IgG1 kappa light chain antibody that detects LSP1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). LSP1 Antibody (TDP153) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LSP1, also known as pp52, is a hematopoietic-expressed gene encoding an F-actin-binding, leukocyte-specific phosphoprotein that regulates leukocyte motility and chemotaxis. LSP1 is predominantly expressed in B and T lymphocytes, granulocytes, and macrophages, while mRNA splice variants not encoding lymphocyte-specific protein are found in non-lymphoid cell lines like myocytes, stromal cells, and fibroblasts, suggesting a broader role in signal transduction. LSP1 is located on human chromosome 11p15.5, a region associated with tumor-related chromosomal translocations in chronic lymphocytic leukemia. LSP1′s promoter contains essential regulatory elements, including an initiator defining unique 5′ terminus of LSP1 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif, critical for expression. Through cytoskeletal binding, LSP1 influences cytoskeletal remodeling, vital for leukocyte functions including movement and chemotactic response, making LSP1 significant for immune function and cancer research studies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LSP1 Antibody (TDP153) References:
- Lymphocyte-specific protein 1: a specific marker of human leucocytes. | Pulford, K., et al. 1999. Immunology. 96: 262-71. PMID: 10233704
- Aberrant expression and localization of the cytoskeleton-binding pp52 (LSP1) protein in hairy cell leukemia. | Miyoshi, EK., et al. 2001. Leuk Res. 25: 57-67. PMID: 11137562
- Leukocyte-specific expression of the pp52 (LSP1) promoter is controlled by the cis-acting pp52 silencer and anti-silencer elements. | Malone, CS., et al. 2001. Gene. 268: 9-16. PMID: 11368895
- Leucocyte-specific protein (LSP1) in malignant lymphoma and Hodgkin's disease. | Marafioti, T., et al. 2003. Br J Haematol. 120: 671-8. PMID: 12588355
- Leukocyte-specific phosphoprotein-1 and PU.1: two useful markers for distinguishing T-cell-rich B-cell lymphoma from lymphocyte-predominant Hodgkin's disease. | Marafioti, T., et al. 2004. Haematologica. 89: 957-64. PMID: 15339679
- Alternatively spliced pp52 mRNA in nonlymphoid stromal cells. | Gimble, JM., et al. 1993. J Immunol. 150: 115-21. PMID: 8417117
- Human lymphocyte-specific pp52 gene is a member of a highly conserved dispersed family. | May, W., et al. 1993. Genomics. 15: 515-20. PMID: 8468046
- Differential interaction of nuclear factors with the leukocyte-specific pp52 promoter in B and T cells. | Omori, SA., et al. 1997. J Immunol. 159: 1800-8. PMID: 9257843
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LSP1 Antibody (TDP153) | sc-53363 | 200 µg/ml | $322.00 | |||
LSP1 Antibody (TDP153): m-IgG Fc BP-HRP Bundle | sc-528566 | 200 µg Ab; 10 µg BP | $361.00 | |||
LSP1 Antibody (TDP153): m-IgGκ BP-HRP Bundle | sc-520972 | 200 µg Ab, 40 µg BP | $361.00 | |||
LSP1 Antibody (TDP153): m-IgG1 BP-HRP Bundle | sc-543000 | 200 µg Ab; 20 µg BP | $361.00 | |||
LSP1 Antibody (TDP153) AC | sc-53363 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LSP1 Antibody (TDP153) HRP | sc-53363 HRP | 200 µg/ml | $322.00 | |||
LSP1 Antibody (TDP153) FITC | sc-53363 FITC | 200 µg/ml | $336.00 | |||
LSP1 Antibody (TDP153) PE | sc-53363 PE | 200 µg/ml | $349.00 | |||
LSP1 Antibody (TDP153) Alexa Fluor® 488 | sc-53363 AF488 | 200 µg/ml | $364.00 | |||
LSP1 Antibody (TDP153) Alexa Fluor® 546 | sc-53363 AF546 | 200 µg/ml | $364.00 | |||
LSP1 Antibody (TDP153) Alexa Fluor® 594 | sc-53363 AF594 | 200 µg/ml | $364.00 | |||
LSP1 Antibody (TDP153) Alexa Fluor® 647 | sc-53363 AF647 | 200 µg/ml | $364.00 | |||
LSP1 Antibody (TDP153) Alexa Fluor® 680 | sc-53363 AF680 | 200 µg/ml | $364.00 | |||
LSP1 Antibody (TDP153) Alexa Fluor® 790 | sc-53363 AF790 | 200 µg/ml | $364.00 |