Lsh Antibody (C-1): sc-365815
- Lsh Antibody (C-1) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 259-287 near the N-terminus of Lsh of mouse origin
- recommended for detection of Lsh of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine
- TransCruz reagent for ChIP application (sc-365815 X, 200 µg/0.1 ml)
- See Lsh (H-4): sc-46665 for Lsh antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Lsh Antibody (C-1) for WB applications. These reagents are now offered in bundles with Lsh Antibody (C-1) (see ordering information below).
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SEE ALSO...
Lsh Antibody (C-1) is a mouse monoclonal IgG2a antibody that detects Lymphoid-Specific Helicase (Lsh) in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Lsh plays a crucial role in the regulation of transcription by altering chromatin structure, which is essential for the proper proliferation of peripheral T lymphocytes and the development of lymphoid tissues. Lsh is predominantly expressed in lymphoid precursor cells, as well as in fetal liver and thymus, highlighting its importance during immune system development. Notably, Lsh exhibits significant homology to other SNF2 family members involved in chromatin remodeling, suggesting a function similar to Mi-2, a known transcriptional silencer. This functional similarity indicates that Lsh may be involved in chromatin repression, thereby regulating gene expression rather than facilitating chromatin accessibility. Anti-Lsh antibody (C-1) serves as an invaluable tool for researchers studying the intricate mechanisms of transcriptional regulation and chromatin dynamics in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Lsh Antibody (C-1) References:
- Isolation and quantification of LSH and the evaluation of related serum basic proteins in normal adults and cancer patients. | Luckey, TD. and Venugopal, B. 1975. Ann N Y Acad Sci. 249: 166-76. PMID: 1055569
- TP53 in gastric cancer: mutations in the l3 loop and LSH motif DNA-binding domains of TP53 predict poor outcome. | Migliavacca, M., et al. 2004. J Cell Physiol. 200: 476-85. PMID: 15254976
- Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/Ity/Bcg genes on chromosome 1. | Cornall, RJ., et al. 1991. Nature. 353: 262-5. PMID: 1832743
- ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis. | Keyes, WM., et al. 2011. Cell Stem Cell. 8: 164-76. PMID: 21295273
- The SNF2 family ATPase LSH promotes phosphorylation of H2AX and efficient repair of DNA double-strand breaks in mammalian cells. | Burrage, J., et al. 2012. J Cell Sci. 125: 5524-34. PMID: 22946062
- CG hypomethylation in Lsh-/- mouse embryonic fibroblasts is associated with de novo H3K4me1 formation and altered cellular plasticity. | Yu, W., et al. 2014. Proc Natl Acad Sci U S A. 111: 5890-5. PMID: 24711395
- The ATP binding site of the chromatin remodeling homolog Lsh is required for nucleosome density and de novo DNA methylation at repeat sequences. | Ren, J., et al. 2015. Nucleic Acids Res. 43: 1444-55. PMID: 25578963
- LSH interacts with and stabilizes GINS4 transcript that promotes tumourigenesis in non-small cell lung cancer. | Yang, R., et al. 2019. J Exp Clin Cancer Res. 38: 280. PMID: 31253190
- GIAT4RA functions as a tumor suppressor in non-small cell lung cancer by counteracting Uchl3-mediated deubiquitination of LSH. | Yang, R., et al. 2019. Oncogene. 38: 7133-7145. PMID: 31417184
- Lymphoid-specific helicase in epigenetics, DNA repair and cancer. | Chen, X., et al. 2022. Br J Cancer. 126: 165-173. PMID: 34493821
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lsh Antibody (C-1) | sc-365815 | 200 µg/ml | $322.00 | |||
Lsh Antibody (C-1): m-IgG Fc BP-HRP Bundle | sc-537842 | 200 µg Ab; 10 µg BP | $361.00 | |||
Lsh Antibody (C-1): m-IgGκ BP-HRP Bundle | sc-535264 | 200 µg Ab; 40 µg BP | $361.00 | |||
Lsh Antibody (C-1): m-IgG2a BP-HRP Bundle | sc-548129 | 200 µg Ab; 10 µg BP | $361.00 | |||
Lsh (C-1) Neutralizing Peptide | sc-365815 P | 100 µg/0.5 ml | $69.00 | |||
Lsh Antibody (C-1) X | sc-365815 X | 200 µg/0.1 ml | $322.00 |