LRRC40 Antibody (C-8): sc-515101
- LRRC40 Antibody (C-8) is a mouse monoclonal IgG2a κ LRRC40 antibody provided at 200 µg/ml
- raised against amino acids 337-570 mapping within an internal region of LRRC40 of human origin
- LRRC40 Antibody (C-8) is recommended for detection of LRRC40 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-LRRC40 Antibody (C-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LRRC40 Antibody (C-8) for WB applications. These reagents are now offered in bundles with LRRC40 Antibody (C-8) (see ordering information below).
LRRC40 Antibody (C-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects LRRC40 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LRRC40 (C-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LRRC40 protein consists of 602 amino acids and features twenty leucine-rich repeats, playing a crucial role in mediating protein-protein interactions vital for various cellular processes, including innate immunity and nervous system development. The leucine-rich repeat (LRR) motif, characterized by a 20-30 amino acid sequence forming a hydrophobic α/β horseshoe fold, accommodates several leucine residues within a tightly packed core, providing a versatile structural framework essential for interaction formation. Mutations in genes encoding LRR-containing proteins, such as LRRC40, have been linked to several human diseases, highlighting LRRC40′s importance in maintaining cellular function and integrity.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LRRC40 Antibody (C-8) References:
- Molecular cloning of a novel membrane glycoprotein, pal, specifically expressed in photoreceptor cells of the retina and containing leucine-rich repeat. | Gomi, F., et al. 2000. J Neurosci. 20: 3206-13. PMID: 10777785
- Lack of blood-brain barrier properties in microvessels of the prelaminar optic nerve head. | Hofman, P., et al. 2001. Invest Ophthalmol Vis Sci. 42: 895-901. PMID: 11274064
- The leucine-rich repeat as a protein recognition motif. | Kobe, B. and Kajava, AV. 2001. Curr Opin Struct Biol. 11: 725-32. PMID: 11751054
- Vascular leucocyte adhesion molecules unaltered in the human retina in diabetes. | Hughes, JM., et al. 2004. Br J Ophthalmol. 88: 566-72. PMID: 15031178
- Differential expression of connective tissue growth factor in microglia and pericytes in the human diabetic retina. | Kuiper, EJ., et al. 2004. Br J Ophthalmol. 88: 1082-7. PMID: 15258030
- Structural analysis of leucine-rich-repeat variants in proteins associated with human diseases. | Matsushima, N., et al. 2005. Cell Mol Life Sci. 62: 2771-91. PMID: 16231091
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LRRC40 Antibody (C-8) | sc-515101 | 200 µg/ml | $322.00 | |||
LRRC40 Antibody (C-8): m-IgGκ BP-HRP Bundle | sc-524934 | 200 µg Ab, 40 µg BP | $361.00 | |||
LRRC40 Antibody (C-8): m-IgG2a BP-HRP Bundle | sc-546177 | 200 µg Ab; 10 µg BP | $361.00 | |||
LRRC40 Antibody (C-8) AC | sc-515101 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LRRC40 Antibody (C-8) HRP | sc-515101 HRP | 200 µg/ml | $322.00 | |||
LRRC40 Antibody (C-8) FITC | sc-515101 FITC | 200 µg/ml | $336.00 | |||
LRRC40 Antibody (C-8) PE | sc-515101 PE | 200 µg/ml | $349.00 | |||
LRRC40 Antibody (C-8) Alexa Fluor® 488 | sc-515101 AF488 | 200 µg/ml | $364.00 | |||
LRRC40 Antibody (C-8) Alexa Fluor® 546 | sc-515101 AF546 | 200 µg/ml | $364.00 | |||
LRRC40 Antibody (C-8) Alexa Fluor® 594 | sc-515101 AF594 | 200 µg/ml | $364.00 | |||
LRRC40 Antibody (C-8) Alexa Fluor® 647 | sc-515101 AF647 | 200 µg/ml | $364.00 | |||
LRRC40 Antibody (C-8) Alexa Fluor® 680 | sc-515101 AF680 | 200 µg/ml | $364.00 | |||
LRRC40 Antibody (C-8) Alexa Fluor® 790 | sc-515101 AF790 | 200 µg/ml | $364.00 |