LRRC18 Antibody (D-2): sc-393659
- LRRC18 Antibody (D-2) is a mouse monoclonal IgG1 κ LRRC18 antibody provided at 200 µg/ml
- raised against amino acids 1-261 representing full length LRRC18 of human origin
- LRRC18 Antibody (D-2) is recommended for detection of LRRC18 of human origin by WB, IP, IF and ELISA
- Anti-LRRC18 Antibody (D-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LRRC18 Antibody (D-2) for WB applications. These reagents are now offered in bundles with LRRC18 Antibody (D-2) (see ordering information below).
LRRC18 Antibody (D-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects LRRC18 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LRRC18 (D-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LRRC18, also known as leucine-rich repeat-containing protein 18, is a 261 amino acid protein characterized by the presence of seven leucine-rich repeats (LRRs), which are essential for mediating protein-protein interactions. These LRRs form a hydrophobic α/β horseshoe fold, providing a versatile structural framework that is crucial for LRRC18′s role in cellular processes. LRRC18 is primarily localized in the cytoplasm and plays a significant role in spermatogenesis and sperm maturation, highlighting LRRC18′s importance in reproductive biology. Additionally, LRRC18 is expressed in two isoforms due to alternative splicing and is encoded by a gene located on human chromosome 10. LRRC18′s ability to interact with other proteins involved in these processes underscores LRRC18′s potential significance in understanding fertility and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LRRC18 Antibody (D-2) References:
- The leucine-rich repeat as a protein recognition motif. | Kobe, B. and Kajava, AV. 2001. Curr Opin Struct Biol. 11: 725-32. PMID: 11751054
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. | Clark, HF., et al. 2003. Genome Res. 13: 2265-70. PMID: 12975309
- Identification of a novel testis-specific gene mtLR1, which is expressed at specific stages of mouse spermatogenesis. | Nie, DS., et al. 2005. Biochem Biophys Res Commun. 328: 1010-8. PMID: 15707978
- Structural analysis of leucine-rich-repeat variants in proteins associated with human diseases. | Matsushima, N., et al. 2005. Cell Mol Life Sci. 62: 2771-91. PMID: 16231091
- Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. | O'Donnell, CJ., et al. 2007. BMC Med Genet. 8 Suppl 1: S4. PMID: 17903303
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LRRC18 Antibody (D-2) | sc-393659 | 200 µg/ml | $322.00 | |||
LRRC18 Antibody (D-2): m-IgG Fc BP-HRP Bundle | sc-530530 | 200 µg Ab; 10 µg BP | $361.00 | |||
LRRC18 Antibody (D-2): m-IgGκ BP-HRP Bundle | sc-524036 | 200 µg Ab, 40 µg BP | $361.00 | |||
LRRC18 Antibody (D-2): m-IgG1 BP-HRP Bundle | sc-544110 | 200 µg Ab; 20 µg BP | $361.00 | |||
LRRC18 Antibody (D-2) AC | sc-393659 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LRRC18 Antibody (D-2) HRP | sc-393659 HRP | 200 µg/ml | $322.00 | |||
LRRC18 Antibody (D-2) FITC | sc-393659 FITC | 200 µg/ml | $336.00 | |||
LRRC18 Antibody (D-2) PE | sc-393659 PE | 200 µg/ml | $349.00 | |||
LRRC18 Antibody (D-2) Alexa Fluor® 488 | sc-393659 AF488 | 200 µg/ml | $364.00 | |||
LRRC18 Antibody (D-2) Alexa Fluor® 546 | sc-393659 AF546 | 200 µg/ml | $364.00 | |||
LRRC18 Antibody (D-2) Alexa Fluor® 594 | sc-393659 AF594 | 200 µg/ml | $364.00 | |||
LRRC18 Antibody (D-2) Alexa Fluor® 647 | sc-393659 AF647 | 200 µg/ml | $364.00 | |||
LRRC18 Antibody (D-2) Alexa Fluor® 680 | sc-393659 AF680 | 200 µg/ml | $364.00 | |||
LRRC18 Antibody (D-2) Alexa Fluor® 790 | sc-393659 AF790 | 200 µg/ml | $364.00 |