LPPR4 Antibody (E-5): sc-515779

LPPR4 Antibody (E-5) is a mouse monoclonal IgG2a antibody that detects LPPR4 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LPPR4, also known as lipid phosphate phosphatase-related protein type 4, is a 763 amino acid multi-pass membrane protein that plays a crucial role in the nervous system by hydrolyzing lysophosphatidic acid (LPA), a lipid mediator involved in various cellular processes. LPPR4 facilitates axonal outgrowth during neuronal development and regenerative sprouting, underscoring LPPR4′s importance in neurobiology, particularly in nerve injury and repair. LPPR4 is exclusively expressed in neurons and exists in two alternatively spliced isoforms, which may contribute to functional diversity. The gene encoding LPPR4 is located on human chromosome 1p21.2, highlighting LPPR4′s significance in human genetics and potential implications in neurological disorders. Anti-LPPR4 antibody (E-5) serves as an essential tool for researchers investigating mechanisms of neuronal signaling and regeneration, providing insights into therapeutic potential of targeting lipid phosphate phosphatases in neurodegenerative diseases.

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LPPR4 Antibody (E-5) References:

1. Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease.  |  Adams, LA., et al. 2013. Hepatology. 57: 590-600. PMID: 23213074
2. Cooperative interactions of LPPR family members in membrane localization and alteration of cellular morphology.  |  Yu, P., et al. 2015. J Cell Sci. 128: 3210-22. PMID: 26183180
3. Impact of genetic polymorphisms associated with nonalcoholic fatty liver disease on HIV-infected individuals.  |  Macias, J., et al. 2015. AIDS. 29: 1927-35. PMID: 26352879
4. The PNPLA3 Genetic Variant rs738409 Influences the Progression to Cirrhosis in HIV/Hepatitis C Virus Coinfected Patients.  |  Núñez-Torres, R., et al. 2016. PLoS One. 11: e0168265. PMID: 27973562
5. Genome-Wide Array Analysis Reveals Novel Genomic Regions and Candidate Gene for Intellectual Disability.  |  Chen, X., et al. 2018. Mol Diagn Ther. 22: 749-757. PMID: 30259421
6. Circular RNA Expression Profiling and Selection of Key Circular RNAs in the Hypothalamus of Heat-Acclimated Rats.  |  Fan, L., et al. 2019. Front Physiol. 10: 1112. PMID: 31555146
7. LPPR4 promotes peritoneal metastasis via Sp1/integrin α/FAK signaling in gastric cancer.  |  Zang, D., et al. 2020. Am J Cancer Res. 10: 1026-1044. PMID: 32266108
8. Development and Validation of a Three-Gene Prognostic Signature Based on Tumor Microenvironment for Gastric Cancer.  |  Wang, Q., et al. 2021. Front Genet. 12: 801240. PMID: 35178071
9. LPA1 receptors in the lateral habenula regulate negative affective states associated with alcohol withdrawal.  |  Ren, Z., et al. 2023. Neuropsychopharmacology. 48: 1567-1578. PMID: 37059867
10. Lysophosphatidic Acid Receptors LPAR5 and LPAR2 Inversely Control Hydroxychloroquine-Evoked Itch and Scratching in Mice.  |  Fischer, C., et al. 2024. Int J Mol Sci. 25: PMID: 39125747

The preferred LPPR4 antibody is LPPR4 Antibody (E-10): sc-377263.