LPPR4 Antibody (E-10): sc-377263

LPPR4 Antibody (E-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects LPPR4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LPPR4 (E-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LPPR4 protein, also known as lipid phosphate phosphatase-related protein type 4, plays a crucial role in the nervous system, as LPPR4 is exclusively expressed in neurons and is essential for hydrolyzing lysophosphatidic acid (LPA), a lipid mediator involved in cell signaling. By facilitating axonal outgrowth during development and regenerative sprouting, LPPR4 contributes significantly to neuronal plasticity and repair mechanisms following injury. This 763 amino acid multi-pass membrane protein belongs to the PA-phosphatase related phosphoesterase family and exists in two alternatively spliced isoforms, with LPPR4 gene located on human chromosome 1p21.2. LPPR4′s ability to modulate lipid signaling pathways underscores LPPR4′s importance in neurobiology and potential implications in neurodegenerative diseases, making anti-LPPR4 antibody (E-10) a valuable tool for researchers studying neuronal function and pathology.

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LPPR4 Antibody (E-10) References:

1. A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting.  |  Bräuer, AU., et al. 2003. Nat Neurosci. 6: 572-8. PMID: 12730698
2. Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family.  |  Savaskan, NE., et al. 2004. Eur J Neurosci. 19: 212-20. PMID: 14750979
3. Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions.  |  Sigal, YJ., et al. 2005. Biochem J. 387: 281-93. PMID: 15801912
4. Identification of differentially expressed mRNA transcripts in drug-resistant versus parental human melanoma cell lines.  |  Tanic, N., et al. 2006. Anticancer Res. 26: 2137-42. PMID: 16827156
5. Novel function of the human presqualene diphosphate phosphatase as a type II phosphatidate phosphatase in phosphatidylcholine and triacylglyceride biosynthesis pathways.  |  Theofilopoulos, S., et al. 2008. Biochim Biophys Acta. 1781: 731-42. PMID: 18930839
6. Lipid phosphate phosphatases and signaling.  |  Brindley, DN. and Pilquil, C. 2009. J Lipid Res. 50 Suppl: S225-30. PMID: 19066402
7. Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases.  |  Brindley, DN., et al. 2009. Biochim Biophys Acta. 1791: 956-61. PMID: 19250975
8. Plasticity-related gene 5 (PRG5) induces filopodia and neurite growth and impedes lysophosphatidic acid- and nogo-A-mediated axonal retraction.  |  Broggini, T., et al. 2010. Mol Biol Cell. 21: 521-37. PMID: 20032306
9. LPPR4 promotes peritoneal metastasis via Sp1/integrin α/FAK signaling in gastric cancer.  |  Zang, D., et al. 2020. Am J Cancer Res. 10: 1026-1044. PMID: 32266108
10. Molecular mechanisms in the miR-33a/LPPR4 pathway regulating unsaturated fatty acid synthesis in bovine mammary epithelial cells.  |  Wu, Y., et al. 2023. Anim Biotechnol. 34: 2636-2648. PMID: 35984635
11. Synaptic activity-dependent changes in the hippocampal palmitoylome.  |  Nasseri, GG., et al. 2022. Sci Signal. 15: eadd2519. PMID: 36473050
12. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.  |  Seki, N., et al. 1997. DNA Res. 4: 345-9. PMID: 9455484

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LPPR4 Antibody (E-10) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-LPPR4 Antibody (E-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LPPR4 Antibody (E-10) Specifications

Alternate Product Name: LPPR4

Product Clone Name: E-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 363-395

Epitope Target: LPPR4

Epitope Species: human

Product Reactivity/Detection: LPPR4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine and bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for LPPR4 Antibody (E-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin