LMP7 Antibody (D-12): sc-365698

LMP7 Antibody (D-12) is a mouse monoclonal IgG2b antibody that detects LMP7 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LMP7 is a crucial component of the proteasome, a multi-catalytic proteinase complex that plays a vital role in the degradation of ubiquitinated proteins, thereby regulating various cellular processes including the cell cycle, apoptosis, and antigen presentation. The proteasome is located in both the nucleus and cytoplasm, where LMP7 maintains cellular homeostasis by removing damaged or misfolded proteins. LMP7, along with LMP2, is particularly important for the MHC class I antigen-processing pathway, as LMP7 enhances the generation of peptides that are presented to cytotoxic T cells, thus facilitating immune responses. Upon stimulation with interferon-gamma, LMP7 is expressed in two forms, LMP7A and LMP7B, which are produced from precursor proteins and are essential for the proteasome′s functionality. LMP7′s ability to interact with various substrates and involvement in the immune response underscore LMP7′s significance in both normal physiology and disease states, making anti-LMP7 antibody (D-12) an invaluable tool for researchers studying proteasome function and immune regulation.

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LMP7 Antibody (D-12) References:

1. Up-regulation of the proteasome subunit LMP7 in tissues of endotoxemic rats.  |  Nelson, JE., et al. 2000. J Lab Clin Med. 135: 324-31. PMID: 10779048
2. The LMP7-K allele of the immunoproteasome exhibits reduced transcript stability and predicts high risk of colon cancer.  |  Fellerhoff, B., et al. 2011. Cancer Res. 71: 7145-54. PMID: 22037870
3. Association between LMP2 and LMP7 gene polymorphisms and the risk of gastric cancer: A case-control study.  |  Ma, X., et al. 2015. Oncol Lett. 10: 509-517. PMID: 26171060
4. The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T cell repertoire.  |  Basler, M., et al. 2018. Eur J Immunol. 48: 419-429. PMID: 29067678
5. Down-regulation of TYK2, CBLB and LMP7 genes expression in relapsing-remitting multiple sclerosis patients treated with interferon-beta.  |  Mazdeh, M., et al. 2018. J Neuroimmunol. 314: 24-29. PMID: 29157944
6. Expression of Immunoproteasome Subunit LMP7 in Breast Cancer and Its Association with Immune-Related Markers.  |  Lee, M., et al. 2019. Cancer Res Treat. 51: 80-89. PMID: 29510614
7. HIV-1 Nef Interacts with LMP7 To Attenuate Immunoproteasome Formation and Major Histocompatibility Complex Class I Antigen Presentation.  |  Yang, Y., et al. 2020. mBio. 11: PMID: 33109760
8. Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia.  |  Du, SH., et al. 2020. Front Immunol. 11: 603278. PMID: 33552061
9. The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 Are Crucial Along the Induction of Cerebral Toxoplasmosis.  |  French, T., et al. 2021. Front Immunol. 12: 619465. PMID: 33968021
10. Immunoproteasome impairment via β5i/LMP7-deletion leads to sustained pancreatic injury from experimental pancreatitis.  |  de Freitas Chama, LL., et al. 2021. J Cell Mol Med. 25: 6786-6799. PMID: 34132031

The preferred LMP7 antibody is LMP7 Antibody (A-12): sc-365699.