LMO2 Antibody (H-10): sc-514514

LMO2 Antibody (H-10) is a mouse monoclonal IgG1 antibody that detects LMO2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LMO2 is a crucial nuclear factor characterized by its conserved LIM domain, which contains a cysteine-rich zinc-binding motif essential for its role in transcriptional regulation. LMO2 is primarily located in the nucleus, where LMO2 participates in the formation of transcriptional regulatory complexes, thereby influencing gene expression. LMO2′s nuclear localization enables interaction with the widely expressed nuclear LIM interactor (NLI), also known as CLIM-1, which enhances the stability and functionality of LMO2 within the transcriptional machinery. LMO2 is differentially expressed in various cell types, including thymic precursor cells and mature T cells, highlighting LMO2′s role in cellular differentiation and development. LMO2′s interaction with other proteins, such as LMO4, further underscores LMO2′s significance in the regulation of gene expression and cellular identity, making LMO2 a vital component in understanding the molecular mechanisms underlying neuronal activity and immune responses.

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LMO2 Antibody (H-10) References:

1. LMO2 and BCL6 are associated with improved survival in primary central nervous system lymphoma.  |  Lossos, C., et al. 2014. Br J Haematol. 165: 640-8. PMID: 24571259
2. Lmo2 (LIM-Domain-Only 2) Modulates Sphk1 (Sphingosine Kinase) and Promotes Endothelial Cell Migration.  |  Matrone, G., et al. 2017. Arterioscler Thromb Vasc Biol. 37: 1860-1868. PMID: 28775072
3. LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis.  |  Morishima, T., et al. 2019. Blood. 134: 1159-1175. PMID: 31366618
4. Conditional Immortalization of Lymphoid Progenitors via Tetracycline-Regulated LMO2 Expression.  |  Koniaeva, E., et al. 2020. Hum Gene Ther. 31: 183-198. PMID: 31760808
5. LMO2 plays differential roles in trophoblast subtypes and is associated with preeclampsia.  |  Chen, Y., et al. 2022. Biochem Biophys Res Commun. 604: 43-50. PMID: 35286869
6. LMO2 expression is frequent in T-lymphoblastic leukemia and correlates with survival, regardless of T-cell stage.  |  Latchmansingh, KA., et al. 2022. Mod Pathol. 35: 1220-1226. PMID: 35322192
7. Cytoplasmic LMO2-LDB1 Complex Activates STAT3 Signaling through Interaction with gp130-JAK in Glioma Stem Cells.  |  Park, CG., et al. 2022. Cells. 11: PMID: 35805116
8. A comprehensive analysis of LMO2 pathogenic regulatory profile during T-lineage development and leukemic transformation.  |  Wang, W., et al. 2022. Oncogene. 41: 4079-4090. PMID: 35851847
9. Identification of a minority population of LMO2+ breast cancer cells that integrate into the vasculature and initiate metastasis.  |  Sikandar, SS., et al. 2022. Sci Adv. 8: eabm3548. PMID: 36351009
10. LMO2 promotes the development of AML through interaction with transcription co-regulator LDB1.  |  Lu, L., et al. 2023. Cell Death Dis. 14: 518. PMID: 37573405

The preferred LMO2 antibody is LMO2 Antibody (1A9-1): sc-65736.