LMO2 Antibody (1A9-1): sc-65736

LMO2 Antibody (1A9-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects LMO2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. LMO2 (1A9-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LMO2 protein plays a crucial role in regulating gene expression, particularly in hematopoiesis and T-cell development. LMO2 is primarily located in the nucleus, where LMO2 functions as a transcriptional regulator by forming complexes with other proteins, such as nuclear LIM interactor (NLI), also known as CLIM-1. This interaction is vital for assembling transcriptional regulatory complexes that modulate target gene expression, influencing cellular differentiation and function. LMO2′s importance in T-cell development is underscored by LMO2 expression in thymic precursor cells, where LMO2 helps orchestrate the differentiation process. Additionally, LMO2 expression is tightly regulated by neuronal activity in the central nervous system, highlighting LMO2′s role in maintaining the differentiated phenotype of neurons. Using anti-LMO2 antibody (1A9-1) in research can provide valuable insights into the molecular mechanisms underlying these critical biological processes.

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LMO2 Antibody (1A9-1) References:

1. Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice.  |  Chervinsky, DS., et al. 1999. Mol Cell Biol. 19: 5025-35. PMID: 10373552
2. Characterization of the Lmo4 gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping.  |  Tse, E., et al. 1999. Mamm Genome. 10: 1089-94. PMID: 10556429
3. Regulation of LMO2 mRNA and protein expression in erythroid differentiation.  |  Brandt, SJ. and Koury, MJ. 2009. Haematologica. 94: 447-8. PMID: 19336746
4. LMO2 (LIM Domain Only 2) and Endothelial Cell Migration in Developmental and Postnatal Angiogenesis.  |  Ganta, VC. and Annex, BH. 2017. Arterioscler Thromb Vasc Biol. 37: 1806-1808. PMID: 28954807
5. LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL.  |  Parvin, S., et al. 2019. Cancer Cell. 36: 237-249.e6. PMID: 31447348
6. The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance.  |  O'Connor, KW., et al. 2024. Leukemia. 38: 951-962. PMID: 38553571
7. Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High Risk.  |  Kimura, S., et al. 2024. Cancer Discov. 14: 1838-1859. PMID: 38916500
8. Expression of LIM protein genes Lmo1, Lmo2, and Lmo3 in adult mouse hippocampus and other forebrain regions: differential regulation by seizure activity.  |  Hinks, GL., et al. 1997. J Neurosci. 17: 5549-59. PMID: 9204936
9. Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis.  |  Kenny, DA., et al. 1998. Proc Natl Acad Sci U S A. 95: 11257-62. PMID: 9736723
10. Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI.  |  Semina, EV., et al. 1998. Mamm Genome. 9: 921-4. PMID: 9799849
11. Identification of the LMO4 gene encoding an interaction partner of the LIM-binding protein LDB1/NLI1: a candidate for displacement by LMO proteins in T cell acute leukaemia.  |  Grutz, G., et al. 1998. Oncogene. 17: 2799-803. PMID: 9840944
12. The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11).  |  Valge-Archer, V., et al. 1998. Oncogene. 17: 3199-202. PMID: 9872335

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LMO2 Antibody (1A9-1) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-LMO2 Antibody (1A9-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LMO2 Antibody (1A9-1) Specifications

Alternate Product Name: LMO2

Product Clone Name: 1A9-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: LMO2

Epitope Species: human

Product Reactivity/Detection: LMO2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for LMO2 Antibody (1A9-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin