LITAF Antibody (D-5): sc-166546

LITAF Antibody (D-5) is a mouse monoclonal IgG2a antibody that detects LITAF in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). LITAF, or LPS-induced TNFα factor, is a nuclear protein that plays a pivotal role in the regulation of tumor necrosis factor alpha (TNFα) gene transcription, which is essential for the inflammatory response to bacterial infections. LITAF mediates the secretion of TNFα and other inflammatory mediators in response to lipopolysaccharide (LPS), a potent stimulator of monocytes and macrophages. High expression levels of LITAF mRNA have been predominantly observed in tissues such as the placenta, peripheral blood leukocytes, lymph nodes, and spleen, highlighting LITAF′s critical role in immune responses. LITAF interacts with various signaling pathways, including the LITAF-Stat6B complex, which further underscores LITAF′s significance in the regulation of inflammatory cytokines. Anti-LITAF antibody (D-5) serves as an invaluable tool for researchers studying the mechanisms of inflammation and immune response in human health and disease.

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LITAF Antibody (D-5) References:

1. SIMPLE/LITAF expression induces the translocation of the ubiquitin ligase itch towards the lysosomal compartments.  |  Eaton, HE., et al. 2011. PLoS One. 6: e16873. PMID: 21326863
2. LITAF mediation of increased TNF-α secretion from inflamed colonic lamina propria macrophages.  |  Bushell, KN., et al. 2011. PLoS One. 6: e25849. PMID: 21984950
3. The feedback loop of LITAF and BCL6 is involved in regulating apoptosis in B cell non-Hodgkin's-lymphoma.  |  Shi, Y., et al. 2016. Oncotarget. 7: 77444-77456. PMID: 27764808
4. The topology, structure and PE interaction of LITAF underpin a Charcot-Marie-Tooth disease type 1C.  |  Ho, AK., et al. 2016. BMC Biol. 14: 109. PMID: 27927196
5. LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor) Regulates Cardiac L-Type Calcium Channels by Modulating NEDD (Neural Precursor Cell Expressed Developmentally Downregulated Protein) 4-1 Ubiquitin Ligase.  |  Moshal, KS., et al. 2019. Circ Genom Precis Med. 12: 407-420. PMID: 31462068
6. The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2.  |  Turan, NN., et al. 2020. J Biol Chem. 295: 18148-18159. PMID: 33093176
7. Involvement of the MicroRNA-1-LITAF Axis in Gastric Cancer Cell Growth and Invasion.  |  Chen, YC., et al. 2020. Anticancer Res. 40: 6247-6256. PMID: 33109562
8. Endosomal recycling tubule scission and integrin recycling involve the membrane curvature-supporting protein LITAF.  |  Wunderley, L., et al. 2021. J Cell Sci. 134: PMID: 34342350
9. Hsp70-Bag3 Module Regulates Macrophage Motility and Tumor Infiltration via Transcription Factor LITAF and CSF1.  |  Avinery, L., et al. 2022. Cancers (Basel). 14: PMID: 36077705
10. Kavain ablates the radio-resistance of IDH-wildtype glioblastoma by targeting LITAF/NF-κB pathway.  |  Yu, J., et al. 2023. Cell Oncol (Dordr). 46: 179-193. PMID: 36464713

The preferred LITAF antibody is LITAF Antibody (C-5): sc-166719.