LIN-41 Antibody (E-1): sc-393352
- LIN-41 Antibody (E-1) is a mouse monoclonal IgG2b κ LIN-41 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 264-532 mapping within an internal region of LIN-41 of human origin
- LIN-41 Antibody (E-1) is recommended for detection of LIN-41 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-LIN-41 Antibody (E-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LIN-41 Antibody (E-1) for WB applications. These reagents are now offered in bundles with LIN-41 Antibody (E-1) (see ordering information below).
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LIN-41 Antibody (E-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects LIN-41 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LIN-41 (E-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LIN-41 protein, also known as tripartite motif-containing 71 (TRIM71), plays a crucial role in regulating cell fate determination during development by encoding microRNAs (miRNAs) that downregulate its own expression through binding to complementary sites on the 3′ untranslated region (UTR) of the LIN-41 gene. This regulatory mechanism ensures the timely expression of LIN-29, a transcription factor essential for adult cell specification. LIN-41 is predominantly expressed in developing limb buds, tail buds, and brachial arches, highlighting its importance in embryonic development. Mutations in the LIN-41 gene can lead to premature differentiation of adult tissues during larval stages, underscoring LIN-41′s critical role in developmental timing and cellular identity.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LIN-41 Antibody (E-1) References:
- The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. | Slack, FJ., et al. 2000. Mol Cell. 5: 659-69. PMID: 10882102
- The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR. | Vella, MC., et al. 2004. Genes Dev. 18: 132-7. PMID: 14729570
- Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. | Bagga, S., et al. 2005. Cell. 122: 553-63. PMID: 16122423
- Analysis of the regulation of lin-41 during chick and mouse limb development. | Lancman, JJ., et al. 2005. Dev Dyn. 234: 948-60. PMID: 16245339
- Reciprocal expression of lin-41 and the microRNAs let-7 and mir-125 during mouse embryogenesis. | Schulman, BR., et al. 2005. Dev Dyn. 234: 1046-54. PMID: 16247770
- Cloning and regulation of the vertebrate homologue of lin-41 that functions as a heterochronic gene in Caenorhabditis elegans. | Kanamoto, T., et al. 2006. Dev Dyn. 235: 1142-9. PMID: 16477647
- Novel gain-of-function alleles demonstrate a role for the heterochronic gene lin-41 in C. elegans male tail tip morphogenesis. | Del Rio-Albrechtsen, T., et al. 2006. Dev Biol. 297: 74-86. PMID: 16806150
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LIN-41 Antibody (E-1) | sc-393352 | 200 µg/ml | $322.00 | |||
LIN-41 Antibody (E-1): m-IgG Fc BP-HRP Bundle | sc-530437 | 200 µg Ab; 10 µg BP | $361.00 | |||
LIN-41 Antibody (E-1): m-IgGκ BP-HRP Bundle | sc-523915 | 200 µg Ab, 40 µg BP | $361.00 | |||
LIN-41 Antibody (E-1) AC | sc-393352 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LIN-41 Antibody (E-1) HRP | sc-393352 HRP | 200 µg/ml | $322.00 | |||
LIN-41 Antibody (E-1) FITC | sc-393352 FITC | 200 µg/ml | $336.00 | |||
LIN-41 Antibody (E-1) PE | sc-393352 PE | 200 µg/ml | $349.00 | |||
LIN-41 Antibody (E-1) Alexa Fluor® 488 | sc-393352 AF488 | 200 µg/ml | $364.00 | |||
LIN-41 Antibody (E-1) Alexa Fluor® 546 | sc-393352 AF546 | 200 µg/ml | $364.00 | |||
LIN-41 Antibody (E-1) Alexa Fluor® 594 | sc-393352 AF594 | 200 µg/ml | $364.00 | |||
LIN-41 Antibody (E-1) Alexa Fluor® 647 | sc-393352 AF647 | 200 µg/ml | $364.00 | |||
LIN-41 Antibody (E-1) Alexa Fluor® 680 | sc-393352 AF680 | 200 µg/ml | $364.00 | |||
LIN-41 Antibody (E-1) Alexa Fluor® 790 | sc-393352 AF790 | 200 µg/ml | $364.00 |