LIN-28 Antibody (C-9): sc-374460
- LIN-28 Antibody (C-9) is a mouse monoclonal IgG2a κ LIN-28 antibody, cited in 8 publications, provided at 200 µg/ml
- raised against amino acids 1-44 mapping at the N-terminus of LIN-28 of human origin
- LIN-28 Antibody (C-9) is recommended for detection of LIN-28 of human origin by WB, IP, IF and ELISA
- Anti-LIN-28 Antibody (C-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-374460 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LIN-28 Antibody (C-9) for WB applications. These reagents are now offered in bundles with LIN-28 Antibody (C-9) (see ordering information below).
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SEE ALSO...
LIN-28 Antibody (C-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects LIN-28 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-LIN-28 antibody (C-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LIN-28 is a highly conserved, RNA-binding protein located primarily in the cytoplasm, playing a crucial role in regulating developmental timing during embryogenesis. LIN-28 presence is particularly significant in embryos, embryonic stem cells, and embryonal carcinoma cells, where LIN-28 influences cellular differentiation and growth. LIN-28 interacts with insulin-like growth factor II (IGF-II), enhancing protein synthesis efficiency in differentiating myoblasts, which is vital for muscle development and regeneration. LIN-28 expression persists in certain adult tissues, including cardiac and skeletal muscle, highlighting LIN-28′s importance in both developmental and adult physiological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LIN-28 Antibody (C-9) References:
- RNA-binding protein Lin28 in cancer and immunity. | Jiang, S. and Baltimore, D. 2016. Cancer Lett. 375: 108-113. PMID: 26945970
- Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities. | Xiong, H., et al. 2017. Oncotarget. 8: 25721-25735. PMID: 28147339
- Beyond an oncogene, Lin28 is a master regulator of cancer progression. | Wang, X., et al. 2018. Histol Histopathol. 33: 327-334. PMID: 28745393
- LIN28: A cancer stem cell promoter for immunotherapy in head and neck squamous cell carcinoma. | Li, M., et al. 2019. Oral Oncol. 98: 92-95. PMID: 31574415
- The Role of LIN28-let-7-ARID3B Pathway in Placental Development. | Ali, A., et al. 2020. Int J Mol Sci. 21: PMID: 32455665
- RNA-binding protein complex LIN28/MSI2 enhances cancer stem cell-like properties by modulating Hippo-YAP1 signaling and independently of Let-7. | Zou, H., et al. 2022. Oncogene. 41: 1657-1672. PMID: 35102250
- Lin28 Regulates Cancer Cell Stemness for Tumour Progression. | Lin, Z., et al. 2022. Cancers (Basel). 14: PMID: 36230562
- Targeting Lin28 axis enhances glypican-3-CAR T cell efficacy against hepatic tumor initiating cell population. | Patra, T., et al. 2023. Mol Ther. 31: 715-728. PMID: 36609146
- Exploring Lin28 proteins: Unravelling structure and functions with emphasis on nervous system malignancies. | Maklad, A., et al. 2023. Life Sci. 335: 122275. PMID: 37984514
- Regulating Protein-RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway. | Oyejobi, GK., et al. 2024. Int J Mol Sci. 25: PMID: 38612395
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LIN-28 Antibody (C-9) | sc-374460 | 200 µg/ml | $322.00 | |||
LIN-28 Antibody (C-9): m-IgG Fc BP-HRP Bundle | sc-529747 | 200 µg Ab; 10 µg BP | $361.00 | |||
LIN-28 Antibody (C-9): m-IgGκ BP-HRP Bundle | sc-522744 | 200 µg Ab, 40 µg BP | $361.00 | |||
LIN-28 Antibody (C-9): m-IgG2a BP-HRP Bundle | sc-547371 | 200 µg Ab; 10 µg BP | $361.00 | |||
LIN-28 Antibody (C-9) X | sc-374460 X | 200 µg/0.1 ml | $322.00 | |||
LIN-28 Antibody (C-9) AC | sc-374460 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LIN-28 Antibody (C-9) HRP | sc-374460 HRP | 200 µg/ml | $322.00 | |||
LIN-28 Antibody (C-9) FITC | sc-374460 FITC | 200 µg/ml | $336.00 | |||
LIN-28 Antibody (C-9) PE | sc-374460 PE | 200 µg/ml | $349.00 | |||
LIN-28 Antibody (C-9) Alexa Fluor® 488 | sc-374460 AF488 | 200 µg/ml | $364.00 | |||
LIN-28 Antibody (C-9) Alexa Fluor® 546 | sc-374460 AF546 | 200 µg/ml | $364.00 | |||
LIN-28 Antibody (C-9) Alexa Fluor® 594 | sc-374460 AF594 | 200 µg/ml | $364.00 | |||
LIN-28 Antibody (C-9) Alexa Fluor® 647 | sc-374460 AF647 | 200 µg/ml | $364.00 | |||
LIN-28 Antibody (C-9) Alexa Fluor® 680 | sc-374460 AF680 | 200 µg/ml | $364.00 | |||
LIN-28 Antibody (C-9) Alexa Fluor® 790 | sc-374460 AF790 | 200 µg/ml | $364.00 |