Limd1 Antibody (E-10): sc-365050

Limd1 Antibody (E-10) is a mouse monoclonal IgG2a antibody that detects LIMD1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). LIMD1, or LIM domain-containing protein 1, is a crucial tumor suppressor that plays a significant role in cellular processes due to three LIM zinc-binding domains, which facilitate essential protein-protein interactions. These interactions are vital for regulating various signaling pathways, particularly in the context of cancer, as LIMD1 has been shown to inhibit tumor growth both in vitro and in vivo. LIMD1′s ability to interact with key regulatory proteins such as SQSTM1, Rb, p62, and TRAF6 underscores LIMD1′s importance in maintaining cellular homeostasis and responding to stress, particularly in osteoclast development. Notably, down-regulation of LIMD1 has been observed in lung cancer, highlighting LIMD1′s potential as a biomarker for tumor progression and a target for therapeutic intervention. With broad species reactivity and versatility in multiple applications, anti-LIMD1 antibody (E-10) is an invaluable tool for researchers investigating the molecular mechanisms underlying cancer and other diseases.

The preferred Limd1 antibody is Limd1 Antibody (H-4): sc-271448.