LEPREL1 Antibody (B-9): sc-377353

LEPREL1 Antibody (B-9) is a mouse monoclonal IgG2a antibody that detects LEPREL1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LEPREL1, also known as P3H2 or MLAT4, is a 708 amino acid protein that plays a crucial role in collagen biosynthesis, folding, and assembly, making LEPREL1 essential for maintaining the structural integrity of various tissues. LEPREL1 is primarily located in the endoplasmic reticulum, where LEPREL1 forms a complex with cartilage-associated protein (CRTAP) and cyclophilin B (CyPB). This complex is vital for the 3-hydroxylation of proline residues in collagen types I, II, and V, which is necessary for normal bone development and overall tissue health. LEPREL1 expression in tissues such as heart, placenta, lung, liver, skeletal muscle, and kidney highlights LEPREL1′s importance in various physiological processes, particularly in the proper formation and maintenance of the extracellular matrix. With a highly conserved C-terminal domain containing critical catalytic residues, LEPREL1 is integral to collagen stability and function, making anti-LEPREL1 antibody (B-9) a valuable tool for researchers studying collagen-related disorders and developmental biology.

The preferred LEPREL1 antibody is LEPREL1 Antibody (H-4): sc-377096.