LEMD1 Antibody (A-6): sc-515122
- LEMD1 Antibody (A-6) is a mouse monoclonal IgG1 κ LEMD1 antibody provided at 200 µg/ml
- raised against amino acids 28-129 mapping within an internal region of LEMD1 of mouse origin
- LEMD1 Antibody (A-6) is recommended for detection of LEMD1 of mouse origin by WB, IP, IF and ELISA
- Anti-LEMD1 Antibody (A-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LEMD1 Antibody (A-6) for WB applications. These reagents are now offered in bundles with LEMD1 Antibody (A-6) (see ordering information below).
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LEMD1 Antibody (A-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects LEMD1 protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LEMD1 (A-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LEMD1, also known as cancer/testis antigen 50, is a 181 amino acid protein characterized by a single LEM domain, which is a conserved motif found in several nuclear-membrane proteins. LEMD1 is primarily localized to the nuclear membrane and is testis-specific, highlighting a potential role in reproductive biology. LEMD1 is produced in multiple isoforms due to alternative splicing, with isoform 6 being particularly relevant as LEMD1 has been detected in a significant proportion of colon cancer tissues. LEMD1 expression is believed to be linked to mitotic processes of rapidly proliferating cancer cells, suggesting a critical role in tumorigenesis. LEMD1 gene is located on human chromosome 1, which is the largest chromosome in the human genome and is associated with various diseases, including schizophrenia and Parkinson′s disease. Understanding LEMD1 function and implications in cellular processes can provide valuable insights into potential use as a biomarker or therapeutic target in cancer research.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LEMD1 Antibody (A-6) References:
- Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. | Blackwood, DH., et al. 2001. Am J Hum Genet. 69: 428-33. PMID: 11443544
- Isolation of LEM domain-containing 1, a novel testis-specific gene expressed in colorectal cancers. | Yuki, D., et al. 2004. Oncol Rep. 12: 275-80. PMID: 15254688
- New insights into the evolution of chromosome 1. | Weise, A., et al. 2005. Cytogenet Genome Res. 108: 217-22. PMID: 15545733
- Chromosome 1 abnormalities in multiple myeloma. | Marzin, Y., et al. 2006. Anticancer Res. 26: 953-9. PMID: 16619492
- Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1. | Watson, ML., et al. 1990. J Exp Med. 172: 263-72. PMID: 1694218
- LEM-Domain proteins: new insights into lamin-interacting proteins. | Wagner, N. and Krohne, G. 2007. Int Rev Cytol. 261: 1-46. PMID: 17560279
- Expression of two testis-specific genes, SPATA19 and LEMD1, in prostate cancer. | Ghafouri-Fard, S., et al. 2010. Arch Med Res. 41: 195-200. PMID: 20682177
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LEMD1 Antibody (A-6) | sc-515122 | 200 µg/ml | $316.00 | |||
LEMD1 Antibody (A-6): m-IgG Fc BP-HRP Bundle | sc-531290 | 200 µg Ab; 10 µg BP | $354.00 | |||
LEMD1 Antibody (A-6): m-IgGκ BP-HRP Bundle | sc-524943 | 200 µg Ab, 40 µg BP | $354.00 | |||
LEMD1 Antibody (A-6) AC | sc-515122 AC | 500 µg/ml, 25% agarose | $416.00 | |||
LEMD1 Antibody (A-6) HRP | sc-515122 HRP | 200 µg/ml | $316.00 | |||
LEMD1 Antibody (A-6) FITC | sc-515122 FITC | 200 µg/ml | $330.00 | |||
LEMD1 Antibody (A-6) PE | sc-515122 PE | 200 µg/ml | $343.00 | |||
LEMD1 Antibody (A-6) Alexa Fluor® 488 | sc-515122 AF488 | 200 µg/ml | $357.00 | |||
LEMD1 Antibody (A-6) Alexa Fluor® 546 | sc-515122 AF546 | 200 µg/ml | $357.00 | |||
LEMD1 Antibody (A-6) Alexa Fluor® 594 | sc-515122 AF594 | 200 µg/ml | $357.00 | |||
LEMD1 Antibody (A-6) Alexa Fluor® 647 | sc-515122 AF647 | 200 µg/ml | $357.00 | |||
LEMD1 Antibody (A-6) Alexa Fluor® 680 | sc-515122 AF680 | 200 µg/ml | $357.00 | |||
LEMD1 Antibody (A-6) Alexa Fluor® 790 | sc-515122 AF790 | 200 µg/ml | $357.00 |