LDLR Antibody (C7): sc-18823

LDLR Antibody (C7) is a mouse monoclonal IgG2b kappa light chain antibody that detects the LDLR protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. LDLR monoclonal antibody (C7) is available in both non-conjugated and various conjugated forms, including agarose, phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. The LDLR, or low-density lipoprotein receptor, plays a crucial role in lipid metabolism by mediating the endocytosis of low-density lipoproteins, which are rich in cholesterol. This process is vital for maintaining cellular cholesterol homeostasis and preventing the accumulation of lipids in the bloodstream. The receptor′s structure includes a series of cysteine-rich class A repeats, epidermal growth factor-like repeats, and YWTD repeats, which are essential for its function and interaction with ligands. Importantly, mutations in the LDLR gene can lead to familial hypercholesterolemia, a genetic disorder characterized by high cholesterol levels and an increased risk of cardiovascular diseases. LDLR monoclonal antibody (C7) enables researchers to gain insights into the mechanisms of cholesterol regulation and the implications of LDLR dysfunction in various health conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

LDLR Antibody (C7) References:

1. Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.  |  Trommsdorff, M., et al. 1999. Cell. 97: 689-701. PMID: 10380922
2. Functional domains of the very low density lipoprotein receptor: molecular analysis of ligand binding and acid-dependent ligand dissociation mechanisms.  |  Mikhailenko, I., et al. 1999. J Cell Sci. 112 (Pt 19): 3269-81. PMID: 10504332
3. Molecular genetics of the LDL receptor gene in familial hypercholesterolemia.  |  Hobbs, HH., et al. 1992. Hum Mutat. 1: 445-66. PMID: 1301956
4. Low-density lipoprotein receptor (LDLR) family orchestrates cholesterol homeostasis.  |  Go, GW. and Mani, A. 2012. Yale J Biol Med. 85: 19-28. PMID: 22461740
5. The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis.  |  Davis, CG., et al. 1987. J Biol Chem. 262: 4075-82. PMID: 3104336
6. The LDLR, APOB, and PCSK9 Variants of Index Patients with Familial Hypercholesterolemia in Russia.  |  Meshkov, A., et al. 2021. Genes (Basel). 12: PMID: 33418990
7. Identification of a PCSK9-LDLR disruptor peptide with in vivo function.  |  Brousseau, ME., et al. 2022. Cell Chem Biol. 29: 249-258.e5. PMID: 34547225
8. LDLR is an entry receptor for Crimean-Congo hemorrhagic fever virus.  |  Xu, ZS., et al. 2024. Cell Res. 34: 140-150. PMID: 38182887
9. LDLR is used as a cell entry receptor by multiple alphaviruses.  |  Zhai, X., et al. 2024. Nat Commun. 15: 622. PMID: 38245515
10. The J.D. mutation in familial hypercholesterolemia: amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors.  |  Davis, CG., et al. 1986. Cell. 45: 15-24. PMID: 3955657
11. Spectrum of LDL receptor gene mutations in heterozygous familial hypercholesterolemia.  |  Day, IN., et al. 1997. Hum Mutat. 10: 116-27. PMID: 9259195
12. Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module.  |  Fass, D., et al. 1997. Nature. 388: 691-3. PMID: 9262405

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LDLR Antibody (C7) has 63 citations in a variety of scientific publications.

Primary antibodies like Anti-LDLR Antibody (C7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LDLR Antibody (C7) Specifications

Alternate Product Name: LDLR

Product Clone Name: C7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: LDLR

Epitope Species: bovine

Product Reactivity/Detection: LDLR

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 63 citations in various scientific publications

Available Conjugates/Forms for LDLR Antibody (C7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, PE: Phycoerythrin